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34株大型菌落支原体的抗生素敏感性研究(作者译)

[Study of antibiotic sensitivity in 34 strains of large colony mycoplasma (author's transl)].

作者信息

Laborde M

出版信息

Pathol Biol (Paris). 1977 Oct;25(8):541-6.

PMID:339167
Abstract

The application of Steer's technic to large colony mycoplasma for the study of antibiotic sensitivities, permitted us to compare the activity of various molecules inhibiting protein synthesis. Among large colony mycoplasmas, only mycoplasma pneumoniae is sensitive to erythromycin but we have already isolated a strain resistant at 400 microgram/ml. This should be remembered during treatment of mycoplasma pneumoniae infections. This species always remains sensitive to tetracycline. Among the latter, doxycyclin and minocyclin are preferred, firstly for their greater efficacy in vitro and secondly their better pharmacodynamic criteria. Gentamicin, tobramycin and chloramphenicol are also active in vitro. No trial in vivo has been carried out.

摘要

将斯特尔技术应用于大型菌落支原体以研究抗生素敏感性,使我们能够比较各种抑制蛋白质合成分子的活性。在大型菌落支原体中,只有肺炎支原体对红霉素敏感,但我们已经分离出一株对400微克/毫升耐药的菌株。在治疗肺炎支原体感染时应牢记这一点。该物种对四环素始终保持敏感。在四环素类药物中,多西环素和米诺环素更受青睐,首先是因为它们在体外具有更高的疗效,其次是它们具有更好的药效学标准。庆大霉素、妥布霉素和氯霉素在体外也有活性。尚未进行体内试验。

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