Fede Ângelo Bezerra de Souza, Pereira Souza Ronaldo, Doi Mauricio, De Brot Marina, Aparecida Bueno de Toledo Osorio Cynthia, Rocha Melo Gondim Guilherme, Casali-da-Rocha Jose Claudio, Jbili Rima, Bitencourt Almir Galvao Vieira, Alves de Souza Juliana, Caparica Bitton Rafael, Baroni Alves Makdissi Fabiana, Moraes Sanches Solange
Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil.
Department of Breast Surgery, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil.
Clin Pract. 2021 Apr 6;11(2):205-215. doi: 10.3390/clinpract11020030.
Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy.
Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor.
mPT is a rare presentation of breast cancer and a challenge in clinical practice. A multidisciplinary approach should take into account some aspects like pathogenic mutations and hereditary syndromes. Oncologic surgery is the fundamental approach, and the use of adjuvant therapies is still controversial due to the lack of clinical trials. Treatment recommendations should be individualized according to patient risk and preferences. Prospective studies are fundamental to clarifying the best treatment for these tumors.
乳腺叶状肿瘤（PT），尤其是恶性叶状肿瘤（mPT），是一种罕见的纤维上皮性肿瘤。复杂的诊断基于病理、放射学和临床检查结果，对于最佳治疗策略仍存在争议。
我们的目的是概述这种罕见肿瘤的临床、病理和治疗方面。
mPT是乳腺癌的一种罕见表现，也是临床实践中的一项挑战。多学科方法应考虑诸如致病突变和遗传综合征等方面。肿瘤外科手术是基本的治疗方法，由于缺乏临床试验，辅助治疗的使用仍存在争议。治疗建议应根据患者风险和偏好进行个体化。前瞻性研究对于明确这些肿瘤的最佳治疗方法至关重要。
