使用肝胆示踪剂[68Ga]Ga-Tmos-DAZA的动态PET/CT对肝肿瘤进行特征分析

Dynamic PET/CT with the Hepatobiliary Tracer [68Ga]Ga-Tmos-DAZA for Characterization of a Hepatic Tumor.

作者信息

Freesmeyer Martin, Greiser Julia, Winkens Thomas, Gühne Falk, Kühnel Christian, Rauchfuß Falk, Tautenhahn Hans-Michael, Drescher Robert

机构信息

Clinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.

Clinic of General, Visceral and Vascular Surgery, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.

出版信息

Diagnostics (Basel). 2021 Apr 6;11(4):660. doi: 10.3390/diagnostics11040660.

DOI:10.3390/diagnostics11040660

PMID:33917643

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8067586/

Abstract

Established imaging modalities for the characterization of liver tumors are computed tomography (CT), magnetical resonance (MR) imaging, sonography, and hepatobiliary scintigraphy. In some cases, their results may be inconclusive or certain examinations not possible due to contraindications. Positron emission tomography (PET)/CT has the capability of dynamic imaging with high temporal resolution. With radiolabeled tri-alkoxysalicyl-1,4-diazepan-6-amine (TAoS-DAZA) tracers, imaging of liver perfusion and hepatobiliary function is possible in a single examination. In the presented case, the PET/CT was performed in a patient with suspected hepatocellular carcinoma and atypical CT findings. PET imaging characteristics were consistent with a hepatocellular carcinoma (HCC). PET with DAZA ligands may be a supplemental method for liver tumor characterization in difficult cases.

摘要

用于肝脏肿瘤特征描述的既定成像方式包括计算机断层扫描（CT）、磁共振（MR）成像、超声检查和肝胆闪烁显像。在某些情况下，由于禁忌症，其结果可能不明确或无法进行某些检查。正电子发射断层扫描（PET）/CT具有高时间分辨率的动态成像能力。使用放射性标记的三烷氧基水杨基-1,4-二氮杂环庚烷-6-胺（TAoS-DAZA）示踪剂，在一次检查中就可以对肝脏灌注和肝胆功能进行成像。在本病例中，对一名疑似肝细胞癌且CT表现不典型的患者进行了PET/CT检查。PET成像特征与肝细胞癌（HCC）一致。使用DAZA配体的PET可能是疑难病例中肝脏肿瘤特征描述的一种补充方法。