Werner Anke, Freesmeyer Martin, Kühnel Christian, Drescher Robert, Greiser Julia
Clinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Diagnostics (Basel). 2023 Mar 16;13(6):1144. doi: 10.3390/diagnostics13061144.
Hepatobiliary scintigraphy is a well-established nuclear imaging method for evaluating liver function and displaying the biliary system, but the spatial and temporal resolution is limited, and, there is still no established PET equivalent. Adapted from the work of Schuhmacher et al. in 1983, the production of a Gallium-labeled substitute, tetrabromophthalein ([Ga]Ga-BP-IDA), was undertaken according to current Good Manufacturing Practice (GMP) standards and proved feasible and reproducible. PET/CT with the radiotracer was performed in two complex patients with hepatocellular carcinoma in preparation for transarterial radioembolization. Due to its high spatial and temporal resolution, localization of areas with impaired liver function and visualization of the biliary system were possible. We could demonstrate that this Gallium-labeled, IDA-based PET tracer is feasible and could advance hepatic and biliary function PET imaging.
肝胆闪烁扫描术是一种成熟的核成像方法，用于评估肝功能和显示胆道系统，但空间和时间分辨率有限，而且目前仍没有与之等效的正电子发射断层显像（PET）技术。根据舒马赫等人1983年的研究成果，按照现行药品生产质量管理规范（GMP）标准制备了一种镓标记的替代物四溴酚酞（[Ga]Ga-BP-IDA），并证明其可行且可重复。对两名患有肝细胞癌的复杂患者进行了使用该放射性示踪剂的PET/CT检查，为经动脉放射性栓塞术做准备。由于其高空间和时间分辨率，能够实现肝功能受损区域的定位以及胆道系统的可视化。我们可以证明，这种基于IDA的镓标记PET示踪剂是可行的，并且可以推动肝脏和胆道功能的PET成像技术发展。
