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一例骨髓移植相关的部分脂肪营养不良病例。

A Case of Bone Marrow Transplant-Associated Partial Lipodystrophy.

作者信息

Khan Zakiyyah, Ali Kabeer, Khan Aliyyah, Teelucksingh Surujpal

机构信息

Internal Medicine, Medical Associates Hospital, Saint Joseph, TTO.

Internal Medicine, Eric Williams Medical Sciences Complex, Champs Fleurs, TTO.

出版信息

Cureus. 2024 Oct 16;16(10):e71641. doi: 10.7759/cureus.71641. eCollection 2024 Oct.

DOI:10.7759/cureus.71641
PMID:39553096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11567169/
Abstract

Lipodystrophy is characterized by abnormal fat distribution and has a broad range of etiologic associations. We present a case of a young Afro-Caribbean female to highlight the clinical features of bone marrow transplant-associated partial lipodystrophy. This review examines and provides diagnostic recommendations for discerning lipodystrophy and its potential cause and also provides follow-up guidance in those diagnosed with bone marrow transplant-associated partial lipodystrophy. We utilize this case to highlight the clinical implications of lipodystrophy and create awareness of this as a potential outcome in childhood cancer survivors.

摘要

脂肪营养不良的特征是脂肪分布异常，且有广泛的病因关联。我们报告一例年轻的非洲加勒比女性病例，以突出骨髓移植相关部分性脂肪营养不良的临床特征。本综述探讨并提供诊断建议，以辨别脂肪营养不良及其潜在病因，同时为诊断为骨髓移植相关部分性脂肪营养不良的患者提供随访指导。我们利用该病例突出脂肪营养不良的临床意义，并提高对这一儿童癌症幸存者潜在结局的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/180e3ffe2f63/cureus-0016-00000071641-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/fdbf6072e6a0/cureus-0016-00000071641-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/8576ad5c6136/cureus-0016-00000071641-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/180e3ffe2f63/cureus-0016-00000071641-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/fdbf6072e6a0/cureus-0016-00000071641-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/8576ad5c6136/cureus-0016-00000071641-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dbe/11567169/180e3ffe2f63/cureus-0016-00000071641-i03.jpg

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1
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本文引用的文献

1
Complications of lipodystrophy syndromes.脂肪营养不良综合征的并发症。
Presse Med. 2021 Nov;50(3):104085. doi: 10.1016/j.lpm.2021.104085. Epub 2021 Oct 30.
2
Lipodystrophy as a Late Effect after Stem Cell Transplantation.脂肪营养不良作为干细胞移植后的晚期效应。
J Clin Med. 2021 Apr 8;10(8):1559. doi: 10.3390/jcm10081559.
3
Metreleptin worked in a diabetic woman with a history of hematopoietic stem cell transplantation (HSCT) during infancy: further support for the concept of 'HSCT-associated lipodystrophy'.米雷替肽在一名曾于婴儿期接受过造血干细胞移植（HSCT）的糖尿病女性中发挥了作用：进一步支持了“HSCT 相关脂肪营养不良”的概念。
Endocr J. 2021 Apr 28;68(4):399-407. doi: 10.1507/endocrj.EJ20-0325. Epub 2020 Nov 21.
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Familial Partial Lipodystrophy (FPLD): Recent Insights.家族性部分性脂肪营养不良（FPLD）：最新见解
Diabetes Metab Syndr Obes. 2020 May 6;13:1531-1544. doi: 10.2147/DMSO.S206053. eCollection 2020.
5
Metreleptin Supplementation for Improving Lipid and Glycemic Profiles in Acquired Diabetes Lipodystrophy: A Case Report.补充米泊明改善获得性糖尿病性脂肪营养不良的血脂和血糖谱：病例报告
J Endocr Soc. 2019 Sep 16;3(11):2179-2183. doi: 10.1210/js.2019-00251. eCollection 2019 Nov 1.
6
Lipodystrophy-like features after total body irradiation among survivors of childhood acute leukemia.儿童急性白血病幸存者全身照射后出现类脂肪营养不良特征
Endocr Connect. 2019 Apr;8(4):349-359. doi: 10.1530/EC-18-0497.
7
Diagnosis and treatment of lipodystrophy: a step-by-step approach.脂代谢障碍的诊断与治疗：分步处理。
J Endocrinol Invest. 2019 Jan;42(1):61-73. doi: 10.1007/s40618-018-0887-z. Epub 2018 Apr 27.
8
Acquired partial lipodystrophy after bone marrow transplant during childhood: a novel syndrome to be added to the disease classification list.儿童期骨髓移植后获得性部分脂肪营养不良：一种需添加到疾病分类列表中的新型综合征。
J Endocrinol Invest. 2017 Nov;40(11):1273-1274. doi: 10.1007/s40618-017-0731-x. Epub 2017 Jul 18.
9
Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey.儿童期接受造血干细胞移植患者的部分脂肪营养不良：一项机构横断面调查。
Clin Pediatr Endocrinol. 2017;26(2):99-108. doi: 10.1297/cpe.26.99. Epub 2017 Apr 22.
10
The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline.脂肪营养不良综合征的诊断与管理：多学会实践指南
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