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使用衰减全反射傅里叶变换红外光谱法对含褪黑素或其衍生物的脂质体凝胶制剂进行特性评估及其黏膜黏附特性研究

Characteristic Evaluation of Gel Formulation Containing Niosomes of Melatonin or Its Derivative and Mucoadhesive Properties Using ATR-FTIR Spectroscopy.

作者信息

Uthaiwat Prangtip, Priprem Aroonsri, Puthongking Ploenthip, Daduang Jureerut, Nukulkit Chatchanok, Chio-Srichan Sirinart, Boonsiri Patcharee, Thapphasaraphong Suthasinee

机构信息

Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand.

Faculty of Pharmacy, Mahasarakham University, Maha Sarakham 44150, Thailand.

出版信息

Polymers (Basel). 2021 Apr 2;13(7):1142. doi: 10.3390/polym13071142.

DOI:10.3390/polym13071142
PMID:33918458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8038236/
Abstract

Chitosan or polyvinyl pyrrolidone (PVP) were used in combination with hydroxypropyl methylcellulose (HPMC) and poloxamer 407 (P407) as gelling agents for oral drug delivery. The performance interaction with mucin of chitosan-composed gel (F1) and PVP-composed gel (F2) was compared using attenuated total reflectance-Fourier-transform infrared (ATR-FTIR) spectroscopy at controlled temperatures of 25 and 37 °C for 1 and 5 min. F1 containing niosome-entrapped melatonin or its derivatives was investigated for mucoadhesive interaction on mucosa by ATR-FTIR spectroscopy under the same conditions. The results showed that F1-treated mucin gave a significantly lower amide I/amide II ratio than untreated mucin and F2-treated mucin did within 1 min, suggesting improved rapid affinity between mucin and chitosan. The spectra of mucosa treated with F1 incorporating niosomes of melatonin or its derivatives showed peak shifts at C=O (amide I), N-H (amide II), and carbohydrate regions and an associated decrease in the amide I/amide II ratio and increase in the carbohydrate/amide II ratio. These results indicated electrostatic interaction and hydrogen bonding between chitosan and mucin on the mucosa. In conclusion, the molecular interaction between gels and mucin/mucosa detected at amide I and amide II of proteins and the carbohydrate region could lead to an improved mucoadhesive property of the gel on the mucosa.

摘要

壳聚糖或聚乙烯吡咯烷酮（PVP）与羟丙基甲基纤维素（HPMC）和泊洛沙姆407（P407）联合用作口服给药的凝胶剂。在25和37°C的控制温度下，分别作用1分钟和5分钟，使用衰减全反射傅里叶变换红外光谱（ATR-FTIR）比较壳聚糖组成的凝胶（F1）和PVP组成的凝胶（F2）与粘蛋白的性能相互作用。在相同条件下，通过ATR-FTIR光谱研究了含有脂质体包裹褪黑素或其衍生物的F1在粘膜上的粘膜粘附相互作用。结果表明，在1分钟内，F1处理的粘蛋白的酰胺I/酰胺II比值明显低于未处理的粘蛋白和F2处理的粘蛋白，这表明粘蛋白与壳聚糖之间的快速亲和力有所提高。用含有褪黑素或其衍生物脂质体的F1处理的粘膜光谱在C=O（酰胺I）、N-H（酰胺II）和碳水化合物区域出现峰位移，酰胺I/酰胺II比值相应降低，碳水化合物/酰胺II比值升高。这些结果表明壳聚糖与粘膜上的粘蛋白之间存在静电相互作用和氢键。总之，在蛋白质的酰胺I和酰胺II以及碳水化合物区域检测到的凝胶与粘蛋白/粘膜之间的分子相互作用可导致凝胶在粘膜上的粘膜粘附性能得到改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/682a3e7c1423/polymers-13-01142-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/3ef8af73c100/polymers-13-01142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/846711d0b452/polymers-13-01142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/b46d5967f919/polymers-13-01142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/412a05781b06/polymers-13-01142-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/79ef97e3ea4b/polymers-13-01142-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/2877a45db6a8/polymers-13-01142-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/491851555774/polymers-13-01142-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/edb1197638e1/polymers-13-01142-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/682a3e7c1423/polymers-13-01142-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/3ef8af73c100/polymers-13-01142-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/846711d0b452/polymers-13-01142-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/b46d5967f919/polymers-13-01142-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/412a05781b06/polymers-13-01142-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/79ef97e3ea4b/polymers-13-01142-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/2877a45db6a8/polymers-13-01142-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/491851555774/polymers-13-01142-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/edb1197638e1/polymers-13-01142-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0267/8038236/682a3e7c1423/polymers-13-01142-g009.jpg

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