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用于早期胃癌诊断的高灵敏度且具有成本效益的便携式传感器。

Highly Sensitive and Cost-Effective Portable Sensor for Early Gastric Carcinoma Diagnosis.

机构信息

State Key Laboratory for THz and Millimeter Waves and Department of Material Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong, China.

Department of Physics, City University of Hong Kong, Kowloon, Hong Kong, China.

出版信息

Sensors (Basel). 2021 Apr 9;21(8):2639. doi: 10.3390/s21082639.

DOI:10.3390/s21082639
PMID:33918707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8069728/
Abstract

Facile and efficient early detection of cancer is a major challenge in healthcare. Herein we developed a novel sensor made from a polycarbonate (PC) membrane with nanopores, followed by sequence-specific Oligo RNA modification for early gastric carcinoma diagnosis. In this design, the gastric cancer antigen CA72-4 is specifically conjugated to the Oligo RNA, thereby inhibiting the electrical current through the PC membrane in a concentration-dependent manner. The device can determine the concentration of cancer antigen CA72-4 in the range from 4 to 14 U/mL, possessing a sensitivity of 7.029 µAUmLcm with a linear regression (R) of 0.965 and a lower detection limit of 4 U/mL. This device has integrated advantages including high specificity and sensitivity and being simple, portable, and cost effective, which collectively enables a giant leap for cancer screening technologies towards clinical use. This is the first report to use RNA aptamers to detect CA72-4 for gastric carcinoma diagnosis.

摘要

癌症的早期检测一直是医疗保健领域的一大挑战。在此，我们开发了一种新型传感器，由具有纳米孔的聚碳酸酯（PC）膜制成，随后进行了针对早期胃癌诊断的寡核苷酸 RNA 修饰。在该设计中，胃癌抗原 CA72-4 特异性地与寡核苷酸 RNA 结合，从而以浓度依赖的方式抑制通过 PC 膜的电流。该设备可以在 4 至 14 U/mL 的范围内确定癌症抗原 CA72-4 的浓度，其灵敏度为 7.029 µAUmLcm，线性回归（R）为 0.965，检测限为 4 U/mL。该设备具有集成优势，包括高特异性和灵敏度，以及简单、便携和经济高效，这些优势共同使癌症筛查技术朝着临床应用迈出了巨大的一步。这是首次使用 RNA 适体检测 CA72-4 用于胃癌诊断的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/b1e7b54c8942/sensors-21-02639-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/ad46d21d7362/sensors-21-02639-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/4ac75a9f4b3d/sensors-21-02639-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/718612dd0083/sensors-21-02639-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/e60627ab2070/sensors-21-02639-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/2899910613a3/sensors-21-02639-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/570c3bfe2784/sensors-21-02639-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/b1e7b54c8942/sensors-21-02639-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/ad46d21d7362/sensors-21-02639-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/31b080433685/sensors-21-02639-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/4ac75a9f4b3d/sensors-21-02639-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/718612dd0083/sensors-21-02639-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/e60627ab2070/sensors-21-02639-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/2899910613a3/sensors-21-02639-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/570c3bfe2784/sensors-21-02639-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ad/8069728/b1e7b54c8942/sensors-21-02639-g008.jpg

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本文引用的文献

1
Surface Analysis of Nanocomplexes by X-ray Photoelectron Spectroscopy (XPS).通过X射线光电子能谱（XPS）对纳米复合物进行表面分析。
ACS Biomater Sci Eng. 2017 Jun 12;3(6):882-889. doi: 10.1021/acsbiomaterials.7b00040. Epub 2017 May 7.
2
A novel 3D paper-based microfluidic electrochemical glucose biosensor based on rGO-TEPA/PB sensitive film.一种基于 rGO-TEPA/PB 敏感膜的新型 3D 纸基微流控电化学葡萄糖生物传感器。
Anal Chim Acta. 2020 Feb 1;1096:34-43. doi: 10.1016/j.aca.2019.10.049. Epub 2019 Oct 23.
3
High-performance modified cellulose paper-based biosensors for medical diagnostics and early cancer screening: A concise review.
一种基于双纳米信号探针的电化学免疫传感器，用于同时检测胃癌中的两种生物标志物。
Biosensors (Basel). 2025 Jan 31;15(2):80. doi: 10.3390/bios15020080.
4
Optimization of Apta-Sensing Platform for Detection of Prostate Cancer Marker PCA3.用于检测前列腺癌标志物 PCA3 的适体传感平台的优化。
Int J Mol Sci. 2021 Nov 24;22(23):12701. doi: 10.3390/ijms222312701.
高性能改性纤维素纸基生物传感器在医学诊断和癌症早期筛查中的应用：简要综述。
Carbohydr Polym. 2020 Feb 1;229:115463. doi: 10.1016/j.carbpol.2019.115463. Epub 2019 Oct 19.
4
Novel RNA aptamers targeting gastrointestinal cancer biomarkers CEA, CA50 and CA72-4 with superior affinity and specificity.针对胃肠道癌生物标志物 CEA、CA50 和 CA72-4 的新型 RNA 适体，具有更高的亲和力和特异性。
PLoS One. 2018 Oct 10;13(10):e0198980. doi: 10.1371/journal.pone.0198980. eCollection 2018.
5
Paper-Based Sensors: Emerging Themes and Applications.基于纸张的传感器：新兴主题与应用。
Sensors (Basel). 2018 Aug 28;18(9):2838. doi: 10.3390/s18092838.
6
Aptamers in the Therapeutics and Diagnostics Pipelines.适体在治疗和诊断中的应用
Theranostics. 2018 Jul 1;8(15):4016-4032. doi: 10.7150/thno.25958. eCollection 2018.
7
Recent Advances in Enhancement Strategies for Electrochemical ELISA-Based Immunoassays for Cancer Biomarker Detection.电化学 ELISA 免疫分析用于癌症生物标志物检测的增强策略的最新进展。
Sensors (Basel). 2018 Jun 22;18(7):2010. doi: 10.3390/s18072010.
8
Aptamer immobilization on amino-functionalized metal-organic frameworks: an ultrasensitive platform for the electrochemical diagnostic of Escherichia coli O157:H7.适配体固定在氨基功能化的金属有机骨架上：用于电化学诊断大肠杆菌 O157:H7 的超灵敏平台。
Analyst. 2018 Jul 7;143(13):3191-3201. doi: 10.1039/c8an00725j. Epub 2018 Jun 14.
9
Aptamer-Based Therapeutic Approaches to Target Cancer Stem Cells.基于适配体的靶向肿瘤干细胞治疗方法。
Theranostics. 2017 Sep 13;7(16):3948-3961. doi: 10.7150/thno.20725. eCollection 2017.
10
Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9.高灵敏度等离子体检测胰腺癌标志物 CA 19-9。
Sci Rep. 2017 Oct 30;7(1):14309. doi: 10.1038/s41598-017-14688-z.