Ansari A H, Pearson O H
Int J Fertil. 1978;23(4):262-9.
Using prolactin suppression (L-dopa) and provocative (thorazine) tests along with the clomid test the intactness of hypothalamico-pituitary axis was assessed in a group of eight patients with galactorrhea syndrome. Pituitary neoplasm was suspected in three cases on the basis of elevated plasma prolactin and its abnormal response to L-dopa, thorazine, and clomid tests. Trans-sphenoidal exploration of the pituitary gland in these three cases confirmed the diagnosis. In these cases, however, the commonly used parameters for evaluation of the pituitary gland (skull X ray, visual field measurement, echoencephalogram, etc.) failed to reveal the presence of the pituitary lesions. In two of the three cases, normal menses recurred following extirpation of the tumors and conception was achieved successfully. In the remaining patient the operation failed to remove the entire pituitary lesion and it was necessary to irradiate the pituitary gland as the patient continued to have persistent galactorrhea and hyperprolactinemia. The importance of the prolactin assay, and its response to stimulation and suppression tests for proper evaluation of galactorrhea was fully discussed.
采用催乳素抑制试验（左旋多巴）、激发试验（氯丙嗪）以及克罗米酚试验，对一组8例溢乳综合征患者的下丘脑 - 垂体轴完整性进行了评估。基于血浆催乳素升高及其对左旋多巴、氯丙嗪和克罗米酚试验的异常反应，3例患者怀疑患有垂体肿瘤。对这3例患者进行经蝶窦垂体探查，确诊了病情。然而，在这些病例中，常用的评估垂体的参数（头颅X线、视野测量、脑回波描记术等）未能显示垂体病变的存在。3例患者中有2例，肿瘤切除后月经恢复正常并成功受孕。在其余1例患者中，手术未能切除全部垂体病变，由于患者持续存在溢乳和高催乳素血症，有必要对垂体进行放射治疗。文中充分讨论了催乳素测定及其对刺激和抑制试验的反应对于正确评估溢乳的重要性。
