Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, Ankara 06330, Turkey.
Biotechnology Research Center of Ministry of Agriculture and Forestry, Yenimahalle, Ankara 06330, Turkey.
Molecules. 2021 Apr 21;26(9):2424. doi: 10.3390/molecules26092424.
Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a fibrin clot. However, delay in the normal wound healing process during pathological conditions due to reactive oxygen species, inflammation and immune suppression at the wound site represents a medical challenge. So far, many therapeutic strategies have been developed to improve cellular homeostasis and chronic wounds in order to accelerate wound repair. In this context, the role of Nuclear factor erythroid 2-related factor 2 (Nrf2) during the wound healing process has been a stimulating research topic for therapeutic perspectives. Nrf2 is the main regulator of intracellular redox homeostasis. It increases cytoprotective gene expression and the antioxidant capacity of mammalian cells. It has been reported that some bioactive compounds attenuate cellular stress and thus accelerate cell proliferation, neovascularization and repair of damaged tissues by promoting Nrf2 activation. This review highlights the importance of the Nrf2 signaling pathway in wound healing strategies and the role of bioactive compounds that support wound repair through the modulation of this crucial transcription factor.
创伤愈合涉及一系列受损细胞和组织中的细胞事件，起始于止血，最终以纤维蛋白凝块的形成为终点。然而，在病理条件下，由于活性氧、炎症和免疫抑制，正常的创伤愈合过程会延迟，这是一个医学挑战。到目前为止，已经开发了许多治疗策略来改善细胞内稳态和慢性创伤，以加速创伤修复。在这种情况下，核因子红细胞 2 相关因子 2（Nrf2）在创伤愈合过程中的作用一直是治疗观点的一个令人兴奋的研究课题。Nrf2 是细胞内氧化还原稳态的主要调节剂。它增加了保护性基因的表达和哺乳动物细胞的抗氧化能力。据报道，一些生物活性化合物通过促进 Nrf2 的激活来减轻细胞应激，从而加速细胞增殖、新血管生成和受损组织的修复。这篇综述强调了 Nrf2 信号通路在创伤愈合策略中的重要性，以及通过调节这一关键转录因子来支持创伤修复的生物活性化合物的作用。
