Jin Ling, Fan Kai, Yao Chunyan, Chang Yongjun, Wang Yang, Lu Jiawei, Yu Shaoqing
Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Department of Allergy,Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
J Inflamm Res. 2024 Oct 15;17:7361-7372. doi: 10.2147/JIR.S476646. eCollection 2024.
The treatment of chronic rhinosinusitis (CRS) is often a difficult and long-term behavior, so it is necessary to seek a local treatment method that can be used for a long time, and is safe and effective. Nasal saline irrigation after functional endoscopic sinus surgery (FESS) is currently recognized as a local treatment method, but it has no anti-inflammatory, anti-damage, and healing-promoting functions. To investigate the efficacy and safety of hydrogen-rich saline (HRS) for nasal irrigation after CRS surgery.
A total of 61 patients after CRS completed the study. Subjects were randomly assigned to rinse the nasal cavity with HRS or normal saline (NS) after CRS. Participants were followed up once a week for 12 times, and were evaluated with visual analogue score (VAS), 22-item Sinonasal Outcomes Test (SNOT-22), and Lund-Kennedy endoscopy scores (LKES). The primary outcome was the VAS score of patients.
After 12 weeks of follow-up, the VAS scores of both groups decreased, and the HRS group (0.52±0.85) was lower than the NS group (1.47±1.55), P=0.005. The total number of cases with complete control (clinical cure) in the short-term efficacy evaluation was more in the HRS group (20/31) than in the NS group (11/30), P=0.03<0.05. No obvious adverse reactions occurred in the two groups during the follow-up.
This study found that HRS was more effective than NS alone in nasal irrigation after CRS surgery, and could shorten the time of nasal mucosal healing and epithelialization, with a higher rate of recent complete control.
慢性鼻-鼻窦炎（CRS）的治疗往往是一项困难且长期的行为，因此有必要寻求一种可长期使用且安全有效的局部治疗方法。功能性鼻内镜鼻窦手术（FESS）后鼻腔盐水冲洗是目前公认的局部治疗方法，但它没有抗炎、抗损伤和促进愈合的功能。本研究旨在探讨富氢盐水（HRS）用于CRS手术后鼻腔冲洗的疗效和安全性。
共有61例CRS术后患者完成本研究。将受试者随机分为CRS术后用HRS或生理盐水（NS）冲洗鼻腔两组。参与者每周随访1次，共随访12次，采用视觉模拟评分（VAS）、22项鼻鼻窦结局测试（SNOT-22）和Lund-Kennedy内镜评分（LKES）进行评估。主要结局指标为患者的VAS评分。
随访12周后，两组患者的VAS评分均降低，HRS组（0.52±0.85）低于NS组（1.47±1.55），P = 0.005。短期疗效评估中，HRS组（20/31）完全控制（临床治愈）的病例总数多于NS组（11/30），P = 0.03<0.05。随访期间两组均未出现明显不良反应。
本研究发现，CRS手术后鼻腔冲洗时，HRS比单用NS更有效，可缩短鼻黏膜愈合和上皮化时间，近期完全控制率更高。
