Hugghins E J, Casper H H, Ward C D
South Dakota State University, Biology Department, Brookings 57007.
J Assoc Off Anal Chem. 1988 May-Jun;71(3):579-81.
A total of 83 black-tailed prairie dogs (Cynomys ludovicianus) from South Dakota were subjected to low-level treatment with sodium monofluoroacetate (Compound 1080) in the laboratory (0.01-0.30 mg 1080/kg). The acute oral median lethal dose (LD50) of 1080 administered by oral gavage was established at 0.173 mg/kg. To assay fluoroacetate residues, 8 kinds of tissue from each of 10 prairie dogs dead of low-level 1080 poisoning were analyzed by capillary gas chromatography-mass spectrometry. Of the total of 79 tissues analyzed, 73 contained less than 100 ppb fluoroacetate, and 67 contained less than 50 ppb fluoroacetate. To test the effect of secondary poisoning on non-target species, 8 European ferrets (Mustela furo) were fed ground whole carcasses of prairie dogs dead of low-level 1080 poisoning, with no observable ill effects on the ferrets.
来自南达科他州的83只黑尾土拨鼠（草原犬鼠）在实验室中接受了低剂量一氟乙酸钠（1080化合物）处理（0.01 - 0.30毫克1080/千克）。经口灌胃给予1080的急性经口半数致死剂量（LD50）确定为0.173毫克/千克。为了测定氟乙酸盐残留量，对10只死于低剂量1080中毒的土拨鼠的8种组织进行了毛细管气相色谱 - 质谱分析。在总共分析的79个组织中，73个组织的氟乙酸盐含量低于100 ppb，67个组织的氟乙酸盐含量低于50 ppb。为了测试二次中毒对非目标物种的影响，给8只欧洲雪貂（白鼬）喂食死于低剂量1080中毒的土拨鼠的全尸绞碎物，雪貂未出现明显不良影响。
