Andrzejewski C, Gault E, Briggs M, Silberstein L
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
J Clin Apher. 1988;4(1):13-7. doi: 10.1002/jca.2920040105.
Plasmapheresis is commonly advocated in cold agglutinin disease with life-threatening hemolysis. Some clinicians, however, are reluctant to use this therapy because of perceived technical problems and risks attendant with the temperature of the extracorporeal circulation. In this study we report our experience of two patients with severe life-threatening hemolysis and in whom plasma exchange was not feasible due to red blood cell autoagglutination in the extracorporeal circuit. A method is described involving the use of blood warmers and the Fenwal CS-3000 blood cell separator with its 37 degrees C centrifuge compartment. The use of plasma exchange in this manner is a safe and beneficial form of adjunctive therapy and should be considered for patients with cold agglutinin disease at risk for extracorporeal agglutination or hemolysis.
血浆置换术常用于伴有危及生命的溶血的冷凝集素病。然而，一些临床医生因察觉到体外循环温度相关的技术问题和风险而不愿使用这种疗法。在本研究中，我们报告了两名患有严重危及生命的溶血且因体外循环中红细胞自身凝集而无法进行血浆置换的患者的治疗经验。本文描述了一种使用血液加温器和带有37摄氏度离心腔的芬华CS - 3000血细胞分离机的方法。以这种方式进行血浆置换是一种安全且有益的辅助治疗形式，对于有体外凝集或溶血风险的冷凝集素病患者应予以考虑。
