Rodenhuis S, Maas A, Hazenberg C A, Das P C, Nieweg H O
Vox Sang. 1985;49(1):20-5. doi: 10.1111/j.1423-0410.1985.tb00763.x.
A therapeutic trial of plasma exchange was conducted in an 82-year-old woman with severe cold agglutinin hemolytic anemia, who was unresponsive to conventional treatment. In spite of considerable improvement of pertinent parameters (total IgM, cold agglutinin titer and thermal amplitude) this treatment failed to induce a clinical remission. This failure may be the result of the ability of the cold agglutinin to fix complement to the red cell membrane at temperatures much higher than the thermal amplitude. A simple laboratory test to detect this dissociation between complement fixing ability and agglutination activity is described.
对一名82岁的严重冷凝集素溶血性贫血女性患者进行了血浆置换治疗试验，该患者对传统治疗无反应。尽管相关参数（总IgM、冷凝集素滴度和热幅度）有相当大的改善，但这种治疗未能诱导临床缓解。这种失败可能是由于冷凝集素在远高于热幅度的温度下仍能将补体固定到红细胞膜上。本文描述了一种简单的实验室检测方法，用于检测补体固定能力和凝集活性之间的这种解离。
