Drozdzik Marek, Drozdzik Maria, Oswald Stefan
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Faculty of Medicine, Medical University of Lodz, 90-419 Lodz, Poland.
Biomedicines. 2021 Apr 14;9(4):426. doi: 10.3390/biomedicines9040426.
The growing information suggests that chronic kidney disease may affect expression and function of membrane carriers and transporters in the kidney. The dysfunction of carriers and transporters entails deficient elimination of uremic solutes as well as xenobiotics (drugs and toxins) with subsequent clinical consequences. The renal carriers and transporters are also targets of drugs used in clinical practice, and intentional drug-drug interactions in the kidney are produced to increase therapeutic efficacy. The understanding of membrane carriers and transporters function in chronic kidney disease is important not only to better characterize drug pharmacokinetics, drug actions in the kidney, or drug-drug interactions but also to define the organ pathophysiology.
越来越多的信息表明，慢性肾脏病可能会影响肾脏中膜载体和转运体的表达及功能。载体和转运体功能障碍会导致尿毒症溶质以及外源性物质（药物和毒素）清除不足，进而产生临床后果。肾脏中的载体和转运体也是临床实践中所用药物的作用靶点，人们会利用肾脏中有意的药物相互作用来提高治疗效果。了解膜载体和转运体在慢性肾脏病中的功能不仅对于更好地描述药物的药代动力学、药物在肾脏中的作用或药物相互作用很重要，而且对于明确器官病理生理学也很重要。
