Department of Cell, Developmental and Integrative Biology, Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Biomolecules. 2021 Apr 15;11(4):577. doi: 10.3390/biom11040577.
The Ca-independent phospholipase Aβ (iPLAβ) is a member of the PLA family that has been proposed to have roles in multiple biological processes including membrane remodeling, cell proliferation, bone formation, male fertility, cell death, and signaling. Such involvement has led to the identification of iPLAβ activation in several diseases such as cancer, cardiovascular abnormalities, glaucoma, periodontitis, neurological disorders, diabetes, and other metabolic disorders. More recently, there has been heightened interest in the role that iPLAβ plays in promoting inflammation. Recognizing the potential contribution of iPLAβ in the development of autoimmune diseases, we review this issue in the context of an iPLAβ link with macrophages and T-cells.
钙非依赖性磷脂酶 Aβ（iPLAβ）是 PLA 家族的一员，被认为在多种生物过程中发挥作用，包括膜重塑、细胞增殖、骨形成、男性生育力、细胞死亡和信号转导。这种参与导致在几种疾病中鉴定出 iPLAβ 的激活，如癌症、心血管异常、青光眼、牙周炎、神经紊乱、糖尿病和其他代谢紊乱。最近，人们对 iPLAβ 在促进炎症中的作用产生了浓厚的兴趣。鉴于 iPLAβ 在自身免疫性疾病发展中的潜在贡献，我们在与巨噬细胞和 T 细胞的联系的背景下审查了这个问题。
