乳腺癌的黑素细胞定植与色素沉着：两例病理病例描述及文献综述

Melanocyte Colonization and Pigmentation of Breast Carcinoma: Description of Two Pathological Cases and Review of Literature.

作者信息

Santoro Angela, Angelico Giuseppe, Fiorentino Vincenzo, Zhang Qianqian, Spadola Saveria, Carlino Angela, Sanchez Alejandro Martin, Franceschini Gianluca, Zannoni Gian Franco, Mulè Antonino

机构信息

Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy.

Department of Woman and Child Health and Public Health, Division of Breast Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Rome, Italy.

出版信息

Diagnostics (Basel). 2021 Apr 15;11(4):709. doi: 10.3390/diagnostics11040709.

DOI:10.3390/diagnostics11040709

PMID:33921072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8071371/

Abstract

Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential.

摘要

1977年，阿佐帕迪和尤塞比首次描述了表皮来源的非肿瘤性黑素细胞对乳腺癌的定植。我们在此报告两例该现象在一名66岁和一名51岁患者中的特殊临床和病理特征。其发病机制尚未完全明了，但基底膜破坏和肿瘤生长因子的作用被认为至关重要。