Das Gupta V, Parasrampuria J, Gardner S N
Department of Pharmaceutics, University of Houston, TX 77030.
J Clin Pharm Ther. 1988 Apr;13(2):165-9. doi: 10.1111/j.1365-2710.1988.tb00174.x.
The chemical stabilities of isoetharine hydrochloride inhalation solution, metaproterenol sulphate inhalation solution and terbutaline sulphate injection, after diluting 1 in 10 with sodium chloride 0.9% injection were studied. On storing the solutions in amber-coloured syringes, they were stable for at least 120 days at 5 degrees C. At 25 degrees C they were also stable for 120 days except that isoetharine solution discoloured and lost 7.8% of its potency after 90 days of storage. There was a new peak in the chromatogram from the decomposition product. All other solutions remained clear for 120 days at both temperatures. The initial and final pH values were similar except that after 120 days at both temperatures. The initial and final pH values were similar except that after 120 days at 25 degrees C, the pH value of terbutaline solution had increased from 4.9 to 5.4.
研究了盐酸异他林吸入溶液、硫酸间羟异丙肾上腺素吸入溶液和硫酸特布他林注射液用0.9%氯化钠注射液按1:10稀释后的化学稳定性。将溶液储存在琥珀色注射器中，在5℃下至少稳定120天。在25℃下，除异他林溶液在储存90天后变色并损失7.8%的效力外，它们也稳定120天。色谱图中出现了分解产物的新峰。在这两个温度下，所有其他溶液在120天内均保持澄清。初始和最终pH值相似，只是在25℃下放置120天后，特布他林溶液的pH值从4.9增加到了5.4。
