Group of Catalysis, Synthesis and Organic Green Chemistry, Department of Pharmaceutical Sciences University of Perugia Via del Liceo 1, 06123 Perugia, Italy.
LASOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, 96010-900 Pelotas, Brazil.
Molecules. 2021 Apr 12;26(8):2224. doi: 10.3390/molecules26082224.
In this work, we present a simple way to achieve 4-arylselanyl-1-1,2,3-triazoles from selenium-containing carbinols in a one-pot strategy. The selenium-containing carbinols were used as starting materials to produce a range of selanyl-triazoles in moderate to good yields, including a quinoline and Zidovudine derivatives. One-pot protocols are crucial to the current concerns about waste production and solvent consumption, avoiding the isolation and purification steps of the reactive terminal selanylalkynes. We could also isolate an interesting and unprecedented by-product with one alkynylselenium moiety connected to the triazole.
在这项工作中，我们提出了一种从含硒仲醇一锅法中简单地合成 4-芳基硒基-1,2,3-三唑的方法。含硒仲醇被用作起始原料，以中等至良好的收率得到了一系列硒基-三唑，包括喹啉和齐多夫定衍生物。一锅法策略对于当前关注的废物产生和溶剂消耗问题至关重要，避免了反应性末端硒基炔烃的分离和纯化步骤。我们还可以分离到一个有趣的、前所未有的副产物，其中一个炔基硒基团连接到三唑上。
