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临床分离株的毒力

Virulence of Clinical Isolates.

作者信息

Mroczyńska Martyna, Brillowska-Dąbrowska Anna

机构信息

Department of Molecular Biotechnology and Microbiology, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland.

出版信息

Pathogens. 2021 Apr 12;10(4):466. doi: 10.3390/pathogens10040466.

DOI:10.3390/pathogens10040466
PMID:33921490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8070227/
Abstract

The factors enabling spp. infections are secretion of hydrolytic enzymes, adherence to surfaces, biofilm formation or morphological transition, and fitness attributes. The aim of this study was to investigate the correlation between known extracellular virulence factors and survival of larvae infected with clinical . The 25 isolates were tested and the activity of proteinases among 24/24, phospholipases among 7/22, esterases among 14/23, hemolysins among 18/24, and biofilm formation ability among 18/25 isolates was confirmed. Pathogenicity investigation using larvae as host model demonstrated that isolates and isolate were the most virulent and isolates were avirulent. virulence was identified as varied, were moderately virulent, and one isolate was of low virulence and the remaining isolates of this species were moderately virulent. According to our study, virulence of isolates is related to the expression of proteases, hemolysins, and esterases.

摘要

导致[具体菌种]感染的因素包括水解酶的分泌、对表面的粘附、生物膜形成或形态转变以及适应性特征。本研究的目的是调查已知细胞外毒力因子与感染临床[具体菌种]的幼虫存活之间的相关性。对25株分离株进行了测试，证实了24/24株中蛋白酶的活性、22株中7株磷脂酶的活性、23株中14株酯酶的活性、24株中18株溶血素的活性以及25株中18株分离株的生物膜形成能力。以幼虫作为宿主模型进行的致病性研究表明，[具体分离株1]和[具体分离株2]分离株毒性最强，[具体分离株3]分离株无毒。[具体菌种]的毒力各不相同，[部分分离株]为中度毒力，一株[具体菌种]分离株为低毒力且该菌种的其余分离株均具有中度毒力。根据我们的研究，[具体菌种]分离株的毒力与蛋白酶、溶血素和酯酶的表达有关。

需注意，原文中存在一些未明确的“spp.”“clinical [具体菌种]”等表述，如果有更明确的信息，译文会更准确。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/9c05dc9c8b2f/pathogens-10-00466-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/5de6fe75bbf0/pathogens-10-00466-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/3285d7831f4d/pathogens-10-00466-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/b21f9638d0be/pathogens-10-00466-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/9c05dc9c8b2f/pathogens-10-00466-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/5de6fe75bbf0/pathogens-10-00466-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/3285d7831f4d/pathogens-10-00466-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/b21f9638d0be/pathogens-10-00466-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c667/8070227/9c05dc9c8b2f/pathogens-10-00466-g004.jpg

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