College of Pharmacy, Mokpo National University, Jeonnam 58554, Korea.
Department of Food and Nutrition, Eulji University, Seongnam 13135, Korea.
Molecules. 2021 Apr 22;26(9):2434. doi: 10.3390/molecules26092434.
Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world's population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic target has not been developed yet. Previously, there have been reports on the benefits of (CT) for treating obesity and diabetes via regulation of metabolic processes, such as lipogenesis, lipolysis, and inflammation. In this study, we investigated the ameliorative effect of orally administered 0.25% and 0.5% (/) CT mixed with high-fat diet (HFD) to C57BL/6J mice for 7 weeks. It was found that body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels were significantly reduced after CT treatment. In CT-treated HFD-fed mice, the mRNA expression levels of hepatic lipogenic and inflammatory cytokine-related genes were markedly reduced, whereas the expression level of epididymal lipogenic genes was increased. The mRNA expression level of beta-oxidation and Nrf-2/HO-1 genes significantly increased in CT-treated obese mice livers. We propose that CT alleviates hepatic steatosis by reducing oxidative stress and inflammation.
非酒精性脂肪性肝病是一种最常见的慢性疾病，影响着广泛的世界人口，并与肥胖引起的代谢综合征有关。它可能正在成为危及生命的肝脏疾病的主要原因，而目前尚未开发出针对这种疾病的具有特定治疗靶点的药物。此前已有报道称，（CT）通过调节脂肪生成、脂肪分解和炎症等代谢过程，对肥胖和糖尿病具有治疗作用。在这项研究中，我们研究了口服给予 0.25%和 0.5%（/）CT 与高脂肪饮食（HFD）混合喂养 7 周对 C57BL/6J 小鼠的改善作用。结果发现，CT 治疗后，体重、脂肪量、肝重、血清葡萄糖水平和肝胆固醇水平均显著降低。在 CT 处理的 HFD 喂养的小鼠中，肝内脂肪生成和炎症细胞因子相关基因的 mRNA 表达水平显著降低，而附睾脂肪生成基因的表达水平增加。CT 处理的肥胖小鼠肝脏中β氧化和 Nrf-2/HO-1 基因的 mRNA 表达水平显著增加。我们提出 CT 通过减少氧化应激和炎症来缓解肝脂肪变性。
