Lathers C M, Spivey W H, Tumer N
Department of Pharmacology, Medical College of Pennsylvania, Philadelphia 19129.
J Clin Pharmacol. 1988 Apr;28(4):289-99. doi: 10.1002/j.1552-4604.1988.tb03146.x.
The reported study determined whether timolol would afford a protective effect by preventing the coronary occlusion-induced arrhythmias associated with the increase in plasma norepinephrine (NE) and epinephrine (E). Ten anesthetized cats received saline or timolol (5 mg/kg, IV) five minutes after coronary occlusion of the left anterior descending coronary artery 10 to 14 mm below its origin. Coronary occlusion produced arrhythmia in three of the cats that received saline and in four of the cats that received timolol. Three of the saline-treated cats died in cardiogenic shock; two were sacrificed six hours postocclusion. Four of the timolol-treated cats died in congestive heart failure postcoronary occlusion. There was a gradual increase in NE (P greater than .05) and E (P less than .05) in both groups after coronary occlusion. Death produced a significant increase in NE and E levels. Timolol did not modify the occurrence of arrhythmias and the associated increase in plasma NE and E that developed after coronary occlusion and at death.
所报道的这项研究确定了噻吗洛尔是否会通过预防与血浆去甲肾上腺素（NE）和肾上腺素（E）增加相关的冠状动脉闭塞诱发的心律失常而发挥保护作用。10只麻醉猫在左冠状动脉前降支距其起始处10至14毫米处冠状动脉闭塞5分钟后，接受生理盐水或噻吗洛尔（5毫克/千克，静脉注射）。冠状动脉闭塞在接受生理盐水的3只猫和接受噻吗洛尔的4只猫中引发了心律失常。3只接受生理盐水治疗的猫死于心源性休克；2只在闭塞后6小时被处死。4只接受噻吗洛尔治疗的猫在冠状动脉闭塞后死于充血性心力衰竭。冠状动脉闭塞后两组的NE（P大于0.05）和E（P小于0.05）均逐渐升高。死亡使NE和E水平显著升高。噻吗洛尔并未改变冠状动脉闭塞后及死亡时出现的心律失常以及血浆NE和E的相关升高。
