Honda T, Ninomiya I
Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Osaka, Japan.
Am J Physiol. 1988 Oct;255(4 Pt 2):H704-10. doi: 10.1152/ajpheart.1988.255.4.H704.
The relationship between adrenal (preganglionic) sympathetic nerve activity (AdSNA), cardiac sympathetic nerve activity (CSNA), and arterial catecholamines, i.e., epinephrine (Epi) and norepinephrine (NE), were analyzed during 200 s of occlusion of left anterior descending coronary artery in anesthetized cats. With coronary occlusion, AdSNA maximally increased to 168 +/- 20% (mean +/- SE) of the control value at 20 s and gradually decreased to 149 +/- 10% at 200 s. Mean CSNA (MCSNA), mean arterial pressure, and heart rate decreased significantly because of coronary occlusion. Arterial NE and Epi progressively increased from 0.54 +/- 0.05 and 0.29 +/- 0.03 ng/ml to 1.41 +/- 0.16 and 0.59 +/- 0.08 ng/ml at 3 min after the onset of occlusion, respectively. The correlation between AdSNA and arterial Epi (r = 0.71; P less than 0.01) and between AdSNA and arterial NE (r = 0.57; P less than 0.05) were significant, but the correlation between CSNA and arterial NE was not significant. On the other hand, in adrenalectomized cats, the increases in arterial Epi and NE did not appear during coronary occlusion. We concluded that, with coronary occlusion, AdSNA increased and, in turn, caused an increase in arterial Epi and NE.
在麻醉猫的左冠状动脉前降支闭塞200秒期间，分析了肾上腺（节前）交感神经活动（AdSNA）、心脏交感神经活动（CSNA）与动脉儿茶酚胺，即肾上腺素（Epi）和去甲肾上腺素（NE）之间的关系。冠状动脉闭塞时，AdSNA在20秒时最大增加至对照值的168±20%（平均值±标准误），并在200秒时逐渐降至149±10%。由于冠状动脉闭塞，平均CSNA（MCSNA）、平均动脉压和心率显著降低。动脉NE和Epi在闭塞开始后3分钟时分别从0.54±0.05和0.29±0.03 ng/ml逐渐增加至1.41±0.16和0.59±0.08 ng/ml。AdSNA与动脉Epi之间的相关性（r = 0.71；P<0.01）以及AdSNA与动脉NE之间的相关性（r = 0.57；P<0.05）显著，但CSNA与动脉NE之间的相关性不显著。另一方面，在肾上腺切除的猫中，冠状动脉闭塞期间动脉Epi和NE未出现增加。我们得出结论，冠状动脉闭塞时，AdSNA增加，进而导致动脉Epi和NE增加。
