Department of Biotechnology, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi-do 13488, Korea.
Pharos Vaccine Inc., 14 Galmachiro 288 bun-gil, Jungwon-gu, Seongnam, Gyeonggi-do 13201, Korea.
Int J Mol Sci. 2021 Apr 23;22(9):4430. doi: 10.3390/ijms22094430.
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role in promoting adaptive immune responses against growing tumors, they also establish and maintain peripheral tolerance. DC activity depends on the method of induction and/or the presence of immunosuppressive agents. Tolerogenic dendritic cells (tDCs) induce immune tolerance by activating CD4CD25Foxp3 regulatory T (Treg) cells and/or by producing cytokines that inhibit T cell activation. These findings suggest that tDCs may be an effective treatment for autoimmune diseases, inflammatory diseases, and infertility.
树突状细胞 (DCs) 是最有效的专业抗原呈递细胞 (APCs) 和 T 细胞介导免疫的诱导剂。尽管 DCs 在促进针对生长肿瘤的适应性免疫反应中发挥核心作用，但它们也建立和维持外周耐受。DC 活性取决于诱导方法和/或免疫抑制剂的存在。致耐受性树突状细胞 (tDCs) 通过激活 CD4CD25Foxp3 调节性 T (Treg) 细胞和/或产生抑制 T 细胞激活的细胞因子来诱导免疫耐受。这些发现表明，tDCs 可能是治疗自身免疫性疾病、炎症性疾病和不育症的有效方法。
