一种新的静脉血栓栓塞实验性猪模型。
A New Experimental Porcine Model of Venous Thromboembolism.
作者信息
Gromadziński Leszek, Skowrońska Agnieszka, Holak Piotr, Smoliński Michał, Lepiarczyk Ewa, Żurada Anna, Majewski Mariusz Krzysztof, Skowroński Mariusz Tomasz, Majewska Marta
机构信息
Department of Cardiology and Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Warszawska Str. 30, 10-082 Olsztyn, Poland.
Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Warszawska Str. 30, 10-082 Olsztyn, Poland.
出版信息
J Clin Med. 2021 Apr 25;10(9):1862. doi: 10.3390/jcm10091862.
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a severe disease affecting the human venous system, accompanied by high morbidity and mortality rates. The aim of the study was to establish a new porcine VTE model based on the formation of the thrombus in vivo. The study was performed on 10 castrated male pigs: thrombus was formed in each closed femoral vein and then successfully released from the right femoral vein into the circulation of animals. In six pigs PE was confirmed via both computed tomography pulmonary angiography and an autopsy. Our research presents a novel experimental porcine model of VTE that involves inducing DVT and PE in the same animal in vivo, making it suitable for advanced clinical research and testing of future therapies.
静脉血栓栓塞症（VTE），包括深静脉血栓形成（DVT）和肺栓塞（PE），是一种影响人体静脉系统的严重疾病，发病率和死亡率都很高。本研究的目的是基于体内血栓形成建立一种新的猪VTE模型。对10头去势雄性猪进行了研究：在每条闭合的股静脉中形成血栓，然后成功地从右股静脉释放到动物循环中。通过计算机断层扫描肺动脉造影和尸检证实了6头猪发生了肺栓塞。我们的研究提出了一种新型的猪VTE实验模型，该模型涉及在同一动物体内诱导DVT和PE，使其适用于高级临床研究和未来治疗方法的测试。
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