肺栓塞的流行病学、病理生理学及自然史
Epidemiology, Pathophysiology, and Natural History of Pulmonary Embolism.
作者信息
Turetz Meredith, Sideris Andrew T, Friedman Oren A, Triphathi Nidhi, Horowitz James M
机构信息
Division of Pulmonary and Critical Care, Department of Medicine, Weill Cornell Medicine, New York, New York.
NYU School of Medicine, New York, New York.
出版信息
Semin Intervent Radiol. 2018 Jun;35(2):92-98. doi: 10.1055/s-0038-1642036. Epub 2018 Jun 4.
Abstract
Pulmonary embolism (PE) is a common and potentially deadly form of venous thromboembolic disease. It is the third most common cause of cardiovascular death and is associated with multiple inherited and acquired risk factors as well as advanced age. The prognosis from PE depends on the degree of obstruction and hemodynamic effects of PE and understanding the pathophysiology helps in risk-stratifying patients and determining treatment. Though the natural history of thrombus is resolution, a subset of patients have chronic residual thrombus, contributing to the post-PE syndrome.
摘要
肺栓塞（PE）是静脉血栓栓塞性疾病中一种常见且可能致命的形式。它是心血管死亡的第三大常见原因，与多种遗传和获得性危险因素以及高龄相关。肺栓塞的预后取决于肺栓塞的阻塞程度和血流动力学影响，了解病理生理学有助于对患者进行风险分层并确定治疗方案。尽管血栓的自然转归是溶解，但一部分患者会有慢性残留血栓，这会导致肺栓塞后综合征。
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