Dube Nondumiso P, Siwe-Noundou Xavier, Krause Rui W M, Kemboi Douglas, Tembu Vuyelwa Jacqueline, Manicum Amanda-Lee
Department of Chemistry, Tshwane University of Technology, 175 Nelson Mandela Drive, Private Bag X680, Pretoria 0001, South Africa.
Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
Molecules. 2021 Apr 16;26(8):2306. doi: 10.3390/molecules26082306.
Species within the genus (Vitaceae) are commonly used in South African traditional medicine. The current review discusses the occurrence, distribution, traditional uses, phytochemistry, and pharmacological properties of species covering the period 1981-2020. The data reported were systematically collected, read, and analysed from scientific electronic databases including Scopus, Scifinder, Pubmed, and Google Scholar. Reported evidence indicates that species in this genus are used for the treatment of gastrointestinal complaints, sexually transmitted infections (STIs), and infertility, as well as to tone the uterus during pregnancy and to facilitate delivery. Pharmacological studies have further shown that members of the genus display antidiabetic, uterotonic, ascaricidal, hepatoprotective, antioxidant, antimicrobial, anticancer, and anti-inflammatory properties. They are linked to the presence of bioactive compounds isolated from the genus. Hence, species can potentially be an alternative therapeutic strategy to treat diseases and develop safer and more potent drugs to combat diseases. Plant species of this genus have valuable medicinal benefits due to their significant pharmacological potential. However, scientific investigation and information of the therapeutic potential of remain limited as most of the species in the genus have not been fully exploited. Therefore, there is a need for further investigations to exploit the therapeutic potential of the genus . Future studies should evaluate the phytochemical, pharmacological, and toxicological activities, as well as the mode of action, of crude extracts and secondary compounds isolated from the species.
葡萄属（葡萄科）植物在南非传统医学中普遍使用。本综述讨论了1981年至2020年期间葡萄属植物的分布、传统用途、植物化学和药理特性。报告的数据是从包括Scopus、Scifinder、Pubmed和谷歌学术在内的科学电子数据库中系统收集、阅读和分析的。报告的证据表明，该属植物用于治疗胃肠道疾病、性传播感染（STIs）和不孕症，以及在怀孕期间调理子宫和促进分娩。药理研究进一步表明，葡萄属植物具有抗糖尿病、子宫收缩、驱虫、保肝、抗氧化、抗菌、抗癌和抗炎特性。它们与从该属中分离出的生物活性化合物有关。因此，葡萄属植物有可能成为治疗疾病的替代治疗策略，并开发更安全、更有效的药物来对抗疾病。该属植物因其显著的药理潜力而具有宝贵的药用价值。然而，由于该属中的大多数物种尚未得到充分开发，对其治疗潜力的科学研究和信息仍然有限。因此，需要进一步研究以开发该属植物的治疗潜力。未来的研究应评估从该属植物中分离出的粗提物和次生化合物的植物化学、药理和毒理学活性以及作用方式。
