Swana Leseho, Tsakem Bienvenu, Tembu Jacqueline V, Teponno Rémy B, Folahan Joy T, Kalinski Jarmo-Charles, Polyzois Alexandros, Kamatou Guy, Sandjo Louis P, Chamcheu Jean Christopher, Siwe-Noundou Xavier
Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria 0208, South Africa.
Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon.
Pharmaceuticals (Basel). 2023 May 22;16(5):775. doi: 10.3390/ph16050775.
Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethnobotanical uses, phytochemistry, and bioactivities of species. The intent is to spur future research into isolating and identifying key active principles, secondary metabolites, and crude extracts, and evaluating their pharmacological and toxicological effects, as well as the mechanism of actions to understand their medicinal benefits. A systematic review of scientific electronic databases from 1963 to 2022 including Scifinder, Scopus, Pubmed, Springer Link, ResearchGate, Ethnobotany Research and Applications, Google Scholar, and ScienceDirect was conducted with a focus on (G.Don) H.J. Lam and (Blume) H.J. Lam. Pharmacological data revealed that isolates contain secondary metabolites and other phytochemical groups belonging to the terpenoids class with anti-microbial, anticancer, antidiabetic, antiinflammatory and hepatoprotective activities, highlighting its pharmacological potential in the therapy or management of diverse cancers, cardiovascular, and neurological diseases. Thus, phytochemicals and standardized extracts from could offer safer and cost-effective chemopreventive and chemotherapeutic health benefits/regimen, or as alternative therapeutic remedy for several human diseases. Nevertheless, the therapeutic potential of most of the plants in the genus have not been exhaustively explored with regard to phytochemistry and pharmacology, but mostly complementary approaches lacking rigorous, scientific research-based knowledge. Therefore, the therapeutic potentials of the genus remain largely untapped, and comprehensive research is necessary to fully harness their medicinal properties.
橄榄科的瓦勒属植物在热带地区的传统医学中被广泛用于治疗一系列疾病，包括疟疾、伤口、扁桃体炎和癣。本综述讨论了该属植物的分布、民族植物学用途、植物化学和生物活性。目的是推动未来对关键活性成分、次生代谢产物和粗提物的分离和鉴定研究，并评估它们的药理和毒理作用以及作用机制，以了解其药用价值。对1963年至2022年的科学电子数据库进行了系统综述，包括Scifinder、Scopus、Pubmed、Springer Link、ResearchGate、《民族植物学研究与应用》、谷歌学术和ScienceDirect，重点关注瓦勒橄榄（G.Don）H.J. Lam和菲律宾瓦勒榄（Blume）H.J. Lam。药理数据显示，瓦勒属植物分离物含有次生代谢产物和其他属于萜类的植物化学基团，具有抗菌、抗癌、抗糖尿病、抗炎和保肝活性，突出了其在治疗或管理多种癌症、心血管和神经疾病方面的药理潜力。因此，瓦勒属植物的植物化学物质和标准化提取物可以提供更安全、更具成本效益的化学预防和化疗健康益处/方案，或作为几种人类疾病的替代治疗方法。然而，该属大多数植物的治疗潜力在植物化学和药理学方面尚未得到充分探索，大多是缺乏严格科学研究知识的补充方法。因此，瓦勒属的治疗潜力在很大程度上仍未被开发，需要进行全面研究以充分利用它们的药用特性。
