丹参酮的骨骼效应：综述。
The Skeletal Effects of Tanshinones: A Review.
机构信息
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Level 17, Preclinical Building, Jalan Yaacob Latif, Bandar Tun Razak, Cheras Kuala Lumpur 56000, Malaysia.
出版信息
Molecules. 2021 Apr 16;26(8):2319. doi: 10.3390/molecules26082319.
BACKGROUND
Osteoporosis results from excessive bone resorption and reduced bone formation, triggered by sex hormone deficiency, oxidative stress and inflammation. Tanshinones are a class of lipophilic phenanthrene compounds found in the roots of with antioxidant and anti-inflammatory activities, which contribute to its anti-osteoporosis effects. This systematic review aims to provide an overview of the skeletal beneficial effects of tanshinones.
METHODS
A systematic literature search was conducted in January 2021 using Pubmed, Scopus and Web of Science from the inception of these databases. Original studies reporting the effects of tanshinones on bone through cell cultures, animal models and human clinical trials were considered.
RESULTS
The literature search found 158 unique articles on this topic, but only 20 articles met the inclusion criteria and were included in this review. The available evidence showed that tanshinones promoted osteoblastogenesis and bone formation while reducing osteoclastogenesis and bone resorption.
CONCLUSIONS
Tanshinones modulates bone remodelling by inhibiting osteoclastogenesis and osteoblast apoptosis and stimulating osteoblastogenesis. Therefore, it might complement existing strategies to prevent bone loss.
背景
骨质疏松症是由性激素缺乏、氧化应激和炎症引起的骨吸收过度和骨形成减少所致。丹参酮是一类在丹参根中发现的脂溶性菲醌类化合物，具有抗氧化和抗炎活性，这有助于其抗骨质疏松作用。本系统评价旨在概述丹参酮对骨骼的有益作用。
方法
2021 年 1 月，我们使用 Pubmed、Scopus 和 Web of Science 对这些数据库的创建时间进行了系统的文献检索。原始研究报告了丹参酮通过细胞培养、动物模型和人体临床试验对骨骼的影响。
结果
文献检索在这一主题上找到了 158 篇独特的文章，但只有 20 篇文章符合纳入标准并被纳入本综述。现有证据表明，丹参酮促进成骨细胞生成和骨形成，同时减少破骨细胞生成和骨吸收。
结论
丹参酮通过抑制破骨细胞生成和成骨细胞凋亡以及刺激成骨细胞生成来调节骨重塑。因此，它可能补充现有的预防骨质流失的策略。
Zotero 插件