Vohra Sunita, Punja Salima, Jou Hsing, Schlegelmilch Michael, Wilson Beverly, Spavor Maria, Grundy Paul, Mackie Andrew S, Conway Jennifer, Hartfield Dawn
Faculty of Medicine and Dentistry, 3-548 Edmonton Clinic Health Academy (ECHA), 11405-87 Avenue, Edmonton, AB T6G 1C9, Canada.
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Children (Basel). 2021 Apr 20;8(4):311. doi: 10.3390/children8040311.
Symptoms of pain, nausea/vomiting, and anxiety (PNVA) are highly prevalent in pediatric inpatients. Poorly managed symptoms can lead to decreased compliance with care, and prolonged recovery times. Pharmacotherapy used to manage PNVA symptoms is of variable effectiveness and carries safety risks. Complementary therapies to manage these symptoms are gaining popularity due to their perceived benefits and low risk of harm. Pediatric integrative medicine (PIM) is the combination of complementary therapies with conventional medicine in pediatric populations. A two-arm, cluster-controlled, pragmatic clinical trial was carried out to compare the effectiveness of a PIM service in conjunction with usual care, versus usual care only to treat PNVA symptoms in hospitalized pediatric patients. The primary outcome was the improvement of PNVA symptom severity using a 10-point numerical rating scale. Participant enrollment occurred between January 2013 and January 2016. A total of 872 participants (usual care = 497; PIM = 375) were enrolled. The PIM therapies significantly reduced PNVA symptom severity ( < 0.001). This study found that a hospital-based PIM service is both safe and effective for alleviating PNVA symptoms. Future research should carry out this work in other pediatric inpatient divisions, and in other sites to determine the reproducibility of findings.
疼痛、恶心/呕吐和焦虑症状（PNVA）在儿科住院患者中非常普遍。症状管理不善会导致对治疗的依从性降低以及恢复时间延长。用于管理PNVA症状的药物治疗效果不一且存在安全风险。由于其公认的益处和低伤害风险，用于管理这些症状的补充疗法越来越受欢迎。儿科综合医学（PIM）是补充疗法与儿科传统医学的结合。开展了一项双臂、整群对照、务实的临床试验，以比较PIM服务联合常规护理与仅采用常规护理治疗住院儿科患者PNVA症状的有效性。主要结局是使用10分数字评定量表评估PNVA症状严重程度的改善情况。研究对象招募于2013年1月至2016年1月期间进行。共招募了872名研究对象（常规护理组 = 497名；PIM组 = 375名）。PIM疗法显著降低了PNVA症状的严重程度（<0.001）。本研究发现，基于医院的PIM服务在缓解PNVA症状方面既安全又有效。未来的研究应在其他儿科住院科室以及其他地点开展此项工作，以确定研究结果的可重复性。
