IRMB, University of Montpellier, INSERM, 34295 Montpellier, France.
IRMB, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Int J Mol Sci. 2021 Apr 13;22(8):3990. doi: 10.3390/ijms22083990.
Aging is associated with a progressive and functional decline of all tissues and a striking increase in many "age-related diseases". Although aging has long been considered an inevitable process, strategies to delay and potentially even reverse the aging process have recently been developed. Here, we review emerging rejuvenation strategies that are based on reprogramming toward pluripotency. Some of these approaches may eventually lead to medical applications to improve healthspan and longevity.
衰老是与所有组织的进行性和功能性衰退以及许多“与年龄相关的疾病”的显著增加相关联的。尽管衰老长期以来一直被认为是一个不可避免的过程，但最近已经开发出了延迟甚至可能逆转衰老过程的策略。在这里，我们综述了基于重编程为多能性的新兴的恢复活力策略。这些方法中的一些最终可能会导致医学应用，以改善健康寿命和延长寿命。
