Department of Genetics, Stanford University, Stanford, CA, USA.
Department of Biology, Stanford University, Stanford, CA, USA.
Nat Cell Biol. 2019 Jan;21(1):32-43. doi: 10.1038/s41556-018-0206-0. Epub 2019 Jan 2.
Ageing is associated with the functional decline of all tissues and a striking increase in many diseases. Although ageing has long been considered a one-way street, strategies to delay and potentially even reverse the ageing process have recently been developed. Here, we review four emerging rejuvenation strategies-systemic factors, metabolic manipulations, senescent cell ablation and cellular reprogramming-and discuss their mechanisms of action, cellular targets, potential trade-offs and application to human ageing.
衰老是所有组织功能下降和许多疾病显著增加的相关因素。尽管衰老长期以来被认为是一条单行道，但最近已经开发出了延迟甚至可能逆转衰老过程的策略。在这里，我们回顾了四种新兴的抗衰老策略——系统性因素、代谢操作、衰老细胞清除和细胞重编程，并讨论了它们的作用机制、细胞靶点、潜在的权衡以及在人类衰老中的应用。
