细胞介导的治疗方法促进肝移植中的操作性耐受。

Division of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN 55905, USA.

Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

Int J Mol Sci. 2021 Apr 13;22(8):4016. doi: 10.3390/ijms22084016.

Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.

利用免疫细胞或肝脏非实质细胞的细胞疗法已经成为一种有潜力的治疗方法，可以促进免疫抑制的撤除，并诱导肝移植（LT）受者的免疫耐受。最近的细胞治疗的临床前和临床试验，包括调节性 T 细胞、调节性树突状细胞和间充质细胞，已经显示出了有希望的结果。在这里，我们简要总结了目前用于诱导 LT 受者免疫耐受的细胞治疗的概念。