Cazzato Gerardo, Colagrande Anna, Romita Paolo, Foti Caterina, Resta Leonardo, Ingravallo Giuseppe
Section of Pathology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari, 70124 Bari, Italy.
Diagnostics (Basel). 2021 Apr 28;11(5):793. doi: 10.3390/diagnostics11050793.
Pilomatrixcarcinoma is a very rare follicular neoplasm that shows matrical differentiation. The majority of these lesions originate de novo, while only a few cases of transformation of pilomatricoma (calcifying epithelioma of Malherbe) have been described in the literature. The neoplasm affects mostly middle-aged males with a male-to-female ratio of 3-4:1. The most common localizations are the face, head, trunk and extremites, though there are a few reports of pilomatrixcarcinoma of the eyelid, eyebrow, axilla and clitorid. Here, we describe the first case of a pilomatrixcarcinoma on the anterolateral surface of the first toe of the left foot of an 83-year-old patient, which developed in less than six months and led to amputation of the distal phalanx. We report a brief review of the current literature with particular emphasis on histopathological features useful for diagnosis.
毛母质癌是一种非常罕见的具有毛母质分化的毛囊肿瘤。这些病变大多为原发性，而文献中仅描述了少数毛母质瘤（马勒布钙化上皮瘤）恶变的病例。该肿瘤主要影响中年男性，男女比例为3 - 4:1。最常见的发病部位是面部、头部、躯干和四肢，不过也有一些关于眼睑、眉毛、腋窝和阴蒂毛母质癌的报道。在此，我们描述了一例83岁患者左足第一趾外侧表面的毛母质癌，该肿瘤在不到六个月的时间内发展，并导致远端趾骨截肢。我们简要回顾了当前文献，特别强调了有助于诊断的组织病理学特征。
