Department XI of Pediatrics-1st Pediatric Discipline, "Victor Babeș" University of Medicine and Pharmacy Timișoara, Eftimie Murgu Sq no 2, 300041 Timișoara, Romania.
1st Pediatric Clinic, "Louis Țurcanu" Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timișoara, Romania.
Nutrients. 2021 Apr 28;13(5):1497. doi: 10.3390/nu13051497.
Selenium, residing in a series of selenoproteins, plays an important role in both female and male reproductive function. Of particular significance for reproduction is the antioxidant glutathione peroxidase (GPx), a main selenoenzyme, whose level is regulated by the availability of Se in the body. We hypothesized that changes in Se status, closely related to GPx activity, would result in an increased risk of reproductive dysfunction in individuals. We retrospectively investigated the serum selenium (SeS) concentrations of 1264 apparently healthy people, aged 16-89 years, from Western Romania. The general analysis revealed a non-normal SeS distribution with a median SeS of 100.26 ± 18.32 μg/L and a significant difference in SeS levels between age groups. The analysis of the young group (16-35 years) revealed that up to 50% of individuals did not reach the SeS threshold corresponding to maximum GPx activity (80 μg/L), and a significant imbalance between the genders was apparent when looking at SeS values outside the range. Our results correlated with the general diminished reproductive ability registered in Romania during the last few years. Serum selenium content proves to offer a proper reflection of the fertility competence of the young population, and its monitoring is important for guiding dietary adjustments and attaining normal reproductive function.
硒存在于一系列的硒蛋白中，在女性和男性生殖功能中都发挥着重要作用。对生殖特别重要的是抗氧化谷胱甘肽过氧化物酶 (GPx)，这是一种主要的硒酶，其水平受体内硒的可用性调节。我们假设硒状态的变化，与 GPx 活性密切相关，会导致个体生殖功能障碍的风险增加。我们回顾性地调查了来自罗马尼亚西部的 1264 名明显健康的 16-89 岁人群的血清硒 (SeS) 浓度。一般分析显示 SeS 分布呈非正态分布，中位数为 100.26±18.32μg/L，且不同年龄组之间的 SeS 水平存在显著差异。对年轻组（16-35 岁）的分析表明，高达 50%的个体未达到与最大 GPx 活性（80μg/L）对应的 SeS 阈值，且当观察范围之外的 SeS 值时，性别之间明显存在不平衡。我们的结果与罗马尼亚近年来普遍下降的生殖能力相吻合。血清硒含量证明可以很好地反映年轻人群的生育能力，其监测对于指导饮食调整和实现正常生殖功能很重要。
