视网膜下丘脑束功能障碍对慢性意识障碍患者褪黑素水平的影响。
Effect of Retinohypothalamic Tract Dysfunction on Melatonin Level in Patients with Chronic Disorders of Consciousness.
作者信息
Kanarskii Mikhail, Nekrasova Julia, Vitkovskaya Svetlana, Pradhan Pranil, Peshkov Sergey, Borisova Elena, Borisov Ilya, Panasenkova Olga, Petrova Marina V, Pryanikov Igor
机构信息
Department for the Study of Chronic Disorder of Consciousness, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 117647 Moscow, Russia.
Department of Anestesiology-Reanimatology, People's Friendship University of Russia, 117198 Moscow, Russia.
出版信息
Brain Sci. 2021 Apr 28;11(5):559. doi: 10.3390/brainsci11050559.
OBJECTIVE
The aim of this study is to compare the secretion level of nocturnal melatonin and the characteristics of the peripheral part of the visual analyzer in patients with chronic disorders of consciousness (DOC).
MATERIALS AND METHODS
We studied the level of melatonin in 22 patients with chronic DOC and in 11 healthy volunteers. The fundus condition was assessed using the ophthalmoscopic method.
RESULTS
The average level of nocturnal melatonin in patients with DOC differed by 80% from the level of indole in healthy volunteers. This reveals a direct relationship between etiology, the level of consciousness, gaze fixation, coma recovery scale-revised score and the level of melatonin secretion. Examination by an ophthalmologist revealed a decrease in the macular reflex in a significant number of DOC patients, which in turn correlates negatively with the time from brain injury and positively with low values of nocturnal melatonin.
目的
本研究旨在比较慢性意识障碍（DOC）患者夜间褪黑素的分泌水平以及视觉分析器外周部分的特征。
材料与方法
我们研究了22例慢性DOC患者和11名健康志愿者的褪黑素水平。使用检眼镜检查法评估眼底状况。
结果
DOC患者夜间褪黑素的平均水平与健康志愿者的吲哚水平相差80%。这揭示了病因、意识水平、凝视固定、昏迷恢复量表修订评分与褪黑素分泌水平之间的直接关系。眼科医生的检查发现，大量DOC患者的黄斑反射减弱，这反过来与脑损伤后的时间呈负相关，与夜间褪黑素的低值呈正相关。
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