Stramecki Filip, Frydecka Dorota, Gawęda Łukasz, Prochwicz Katarzyna, Kłosowska Joanna, Samochowiec Jerzy, Szczygieł Krzysztof, Pawlak Edyta, Szmida Elżbieta, Skiba Paweł, Cechnicki Andrzej, Misiak Błażej
Department of Psychiatry, Wroclaw Medical University, Pasteur Street 10, 50-367 Wroclaw, Poland.
Clinical Neuroscience Lab, Institute of Psychology, Polish Academy of Sciences, Jaracza Street 1, 00-378 Warsaw, Poland.
Brain Sci. 2021 Apr 28;11(5):561. doi: 10.3390/brainsci11050561.
Common variations of the gene are implicated in psychotic disorders, by modulating the hypothalamic-pituitary-adrenal axis reactivity to stress. It has been demonstrated that some of them might moderate the effects of childhood trauma on psychosis proneness. However, these associations have not been investigated with respect to traumatic life events (TLEs). Therefore, we aimed to explore whether the polymorphisms moderate the effects of TLEs on the level of psychotic-like experiences (PLEs). A total of 535 non-clinical adults were approached for participation, and genotyping of six polymorphisms (rs3800373, rs9470080, rs4713902, rs737054, rs1360780 and rs9296158) was performed. The Prodromal Questionnaire-16 (PQ-16) and the Traumatic Events Checklist (TEC) were administered to assess PLEs and TLEs, respectively. Among the rs1360780 CC homozygotes, a history of physical abuse was associated with significantly higher PQ-16 scores. This difference was not significant in the rs1360780 T allele carriers. Similarly, a history of physical abuse was associated with significantly higher PQ-16 scores in the rs9296158 GG homozygotes but not in the rs9296158 A allele carriers. Finally, emotional neglect was related to significantly higher PQ-16 scores in the rs737054 T allele carriers but not in the rs737054 CC homozygotes. The present study indicates that variation in the gene might moderate the effects of lifetime traumatic events on psychosis proneness.
该基因的常见变异通过调节下丘脑 - 垂体 - 肾上腺轴对应激的反应性，与精神障碍有关。已经证明，其中一些变异可能会缓和童年创伤对精神病易感性的影响。然而，尚未针对创伤性生活事件（TLEs）对这些关联进行研究。因此，我们旨在探讨这些多态性是否会缓和TLEs对类精神病体验（PLEs）水平的影响。共有535名非临床成年人参与，对六个多态性（rs3800373、rs9470080、rs4713902、rs737054、rs1360780和rs9296158）进行了基因分型。分别使用前驱症状问卷 - 16（PQ - 16）和创伤事件清单（TEC）来评估PLEs和TLEs。在rs1360780 CC纯合子中，身体虐待史与显著更高的PQ - 16得分相关。在rs1360780 T等位基因携带者中，这种差异不显著。同样，在rs9296158 GG纯合子中，身体虐待史与显著更高的PQ - 16得分相关，但在rs9296158 A等位基因携带者中并非如此。最后，情感忽视与rs737054 T等位基因携带者中显著更高的PQ - 16得分相关，但在rs737054 CC纯合子中并非如此。本研究表明，该基因的变异可能会缓和终身创伤事件对精神病易感性的影响。
