Sidorkiewicz Malgorzata
Department of Medical Biochemistry, Faculty of Health Sciences, Medical University of Lodz, 90-419 Lodz, Poland.
Metabolites. 2021 Apr 27;11(5):273. doi: 10.3390/metabo11050273.
Lipids and lipoproteins constitute indispensable components for living not only for humans. In the case of hepatitis C virus (HCV), the option of using the products of our lipid metabolism is "to be, or not to be". On the other hand, HCV infection, which is the main cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma, exerts a profound influence on lipid and lipoprotein metabolism of the host. The consequences of this alternation are frequently observed as hypolipidemia and hepatic steatosis in chronic hepatitis C (CHC) patients. The clinical relevance of these changes reflects the fact that lipids and lipoprotein play a crucial role in all steps of the life cycle of HCV. The virus circulates in the bloodstream as a highly lipidated lipo-viral particle (LVP) that defines HCV hepatotropism. Thus, strict relationships between lipids/lipoproteins and HCV are indispensable for the mechanism of viral entry into hepatocytes, viral replication, viral particles assembly and secretion. The purpose of this review is to summarize the tricks thanks to which HCV utilizes host lipid metabolism to its own advantage.
脂质和脂蛋白不仅是人类生存不可或缺的组成部分。就丙型肝炎病毒（HCV）而言，利用我们脂质代谢产物的选择是“生存还是毁灭”。另一方面，作为慢性肝炎、肝硬化和肝细胞癌的主要病因，HCV感染对宿主的脂质和脂蛋白代谢产生深远影响。这种改变的后果在慢性丙型肝炎（CHC）患者中经常表现为低脂血症和肝脂肪变性。这些变化的临床相关性反映了脂质和脂蛋白在HCV生命周期的所有阶段都起着关键作用这一事实。该病毒以高度脂化的脂病毒颗粒（LVP）形式在血液中循环，这决定了HCV的嗜肝性。因此，脂质/脂蛋白与HCV之间的严格关系对于病毒进入肝细胞、病毒复制、病毒颗粒组装和分泌机制而言不可或缺。本综述的目的是总结HCV利用宿主脂质代谢为自身谋利的诀窍。
