Center of Investigation in Clinical Nutrition, Université catholique de Louvain, Place Pierre de Coubertin 1, Bte L8.10.02, 1348 Louvain-la-Neuve, Belgium.
Comercial Quimica Masso, Viladomat, 321, 5º-08029 Barcelona, Spain.
Nutrients. 2021 Apr 27;13(5):1473. doi: 10.3390/nu13051473.
A saffron extract has been found to be effective in the context of depression and anxiety, but its effect on sleep quality has not been investigating yet using objective approaches. For this purpose, a randomized double-blind controlled study was conducted in subjects presenting mild to moderate sleep disorder associated with anxiety. Sixty-six subjects were randomized and supplemented with a placebo (maltodextrin) or a saffron extract (15.5 mg per day) for 6 weeks. Actigraphy was used to collect objective data related to sleep quality at baseline, at the middle and at the end of the intervention. Sleep quality was also assessed by completion of the LSEQ and PSQI questionnaires and quality of life by completion of the SF-36 questionnaire. Six weeks of saffron supplementation led to an increased time in bed assessed by actigraphy, to an improved ease of getting to sleep evaluated by the LSEQ questionnaire and to an improved sleep quality, sleep latency, sleep duration, and global scores evaluated by the PSQI questionnaire, whereas those parameters were not modified by the placebo. In conclusion, those results suggest that a saffron extract could be a natural and safe nutritional strategy to improve sleep duration and quality.
藏红花提取物已被证明在抑郁和焦虑的情况下有效，但尚未使用客观方法研究其对睡眠质量的影响。为此，在伴有焦虑的轻度至中度睡眠障碍的受试者中进行了一项随机双盲对照研究。66 名受试者被随机分配并补充安慰剂（麦芽糊精）或藏红花提取物（每天 15.5 毫克）6 周。通过活动记录仪收集与睡眠质量相关的客观数据，基线时、干预中期和干预结束时。通过完成 LSEQ 和 PSQI 问卷评估睡眠质量，并通过完成 SF-36 问卷评估生活质量。藏红花补充 6 周可通过活动记录仪评估增加卧床时间，通过 LSEQ 问卷评估入睡容易程度，通过 PSQI 问卷评估睡眠质量、入睡潜伏期、睡眠时间和总体评分得到改善，而安慰剂则不会改变这些参数。总之，这些结果表明藏红花提取物可能是一种天然、安全的营养策略，可以改善睡眠持续时间和质量。
