综合睡眠管理:从分子途径到传统与草药治疗
Integrative sleep management: from molecular pathways to conventional and herbal treatments.
作者信息
Ebrahim Yasmina M, Sadek Mohamed A, Sabry Miral O, Lotfy Rana M, El-Dessouki Ahmed M, Abou-Hussein Dina, El-Shiekh Riham A, ElBishbishy Rana M
机构信息
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 8. doi: 10.1007/s00210-025-04183-y.
Sleep is regarded as one of the most crucial factors in keeping a healthy lifestyle. To function normally, a person needs at least 6-8 h of sleep per day. Sleep influences not only our mood but also the efficiency with which we complete tasks. Sleep disorders exhibit diverse etiologies across different conditions and populations, with genetic and environmental factors playing a significant role in their development. Many issues emerge as a result of inadequate sleep. Unhealthy food and lifestyle choices have increased our susceptibility to sleep disorders. A well-balanced diet rich in essential vitamins and minerals can have a profound impact on sleep patterns, enhancing both the duration and quality of rest. The primary categories of sleep disorders include insomnia, sleep apnea (SA), narcolepsy, parasomnias, circadian rhythm disorders, and restless legs syndrome (RLS). The drugs used to treat sleep disorders are primarily habit-forming and have a history of withdrawal effects. This insufficiency in medication has prompted the hunt for newer, better options. Nutraceuticals are well-suited to the treatment of such illnesses. Its non-toxic, non-habit-forming properties, and practical efficiency have made it an outstanding choice. This review provides nutraceuticals used in sleep disorders. A comprehensive literature search was conducted utilizing several databases, including Google Scholar, Elsevier, Springer Nature, Wiley, PubMed, and EKB. Nutraceuticals are products that employ food or dietary components to treat or prevent disease. In the therapy of sleep disorders, nutraceuticals such as Artemisia annua, valerian, rosemary, jujube, Passionflower, lemon balm, ashwagandha, kava-kava, lavender, and chamomile have been shown to have remarkable benefits. These remedies exert their effects through multiple mechanisms, both directly by modulating neurotransmitter and hormonal pathways within sleep circuits, and indirectly by enhancing sleep quality through the alleviation of stress, inflammation, and oxidative stress. Clinical studies were piloted to validate the efficacy of natural sleep aids. Future research should focus on elucidating the precise mechanisms through which natural products influence sleep.
睡眠被视为保持健康生活方式的最关键因素之一。为了正常运转,一个人每天至少需要6至8小时的睡眠。睡眠不仅影响我们的情绪,还影响我们完成任务的效率。睡眠障碍在不同情况和人群中表现出多样的病因,遗传和环境因素在其发生发展中起着重要作用。睡眠不足会引发许多问题。不健康的食物和生活方式选择增加了我们患睡眠障碍的易感性。富含必需维生素和矿物质的均衡饮食会对睡眠模式产生深远影响,增加休息的时长和质量。睡眠障碍的主要类型包括失眠、睡眠呼吸暂停(SA)、发作性睡病、异态睡眠、昼夜节律紊乱和不宁腿综合征(RLS)。用于治疗睡眠障碍的药物主要有成瘾性,且有停药效应的历史。这种药物治疗的不足促使人们寻找更新、更好的选择。营养保健品非常适合治疗此类疾病。其无毒、无成瘾性以及实际效果使其成为一个出色的选择。本综述介绍了用于睡眠障碍的营养保健品。利用多个数据库进行了全面的文献检索,包括谷歌学术、爱思唯尔、施普林格自然、威利、PubMed和EKB。营养保健品是利用食物或膳食成分来治疗或预防疾病的产品。在睡眠障碍的治疗中,诸如青蒿、缬草、迷迭香、枣、西番莲、蜜蜂花、南非醉茄、卡瓦胡椒、薰衣草和洋甘菊等营养保健品已显示出显著益处。这些疗法通过多种机制发挥作用,既直接通过调节睡眠回路中的神经递质和激素途径,又间接通过减轻压力、炎症和氧化应激来提高睡眠质量。开展了临床研究以验证天然助眠剂的疗效。未来的研究应专注于阐明天然产品影响睡眠的确切机制。