Nguyen Huong Thi Thu, Vu Dung Chi, Nguyen Duc Minh, Dang Quang Dinh, Tran Van Khanh, Le Hung, Tong Son Minh
School of Odonto-Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam.
Department of Endocrinology, Metabolism and Genetics, Vietnam National Children's Hospital, Hanoi 100000, Vietnam.
Dent J (Basel). 2021 Apr 27;9(5):49. doi: 10.3390/dj9050049.
Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility and low bone mass, caused mainly by mutations in collagen type I encoding genes. The current study aimed to evaluate dentinogenesis imperfecta (DI), oral manifestations and caries status of OI children. Sixty-eight children (41 males, 27 females) aged from 3 to 17 years old (mean 9 ± 4.13) participated in the study. Participants were classified into three OI type groups (I-2 cases, III-31 cases and IV-35 cases). Clinical examination and an orthopantomogram were used to obtain prevalences and associations of DI, caries status, malocclusion, crossbite, open bite, eruption, impaction and missing teeth with OI. The prevalence of DI among OI patients was 47.1%, more common in OI type III than type IV. The yellow-brown discoloration type was more vulnerable to attrition than the opalescent-grey one in the primary dentition. OI seemed not to have a high risk of caries; the prevalence of caries was 69.1%. A high incidence of malocclusion, crossbite and open bite was observed. In-depth oral information would provide valuable data for better dental management in OI patients. Parents and general doctors should pay more attention to dental care to prevent caries and premature tooth loss.
成骨不全症（OI）是一种遗传性疾病，其特征是骨脆性增加和骨量低，主要由I型胶原蛋白编码基因突变引起。本研究旨在评估OI患儿的牙本质发育不全（DI）、口腔表现和龋齿状况。68名年龄在3至17岁（平均9±4.13岁）的儿童（41名男性，27名女性）参与了研究。参与者被分为三个OI类型组（I型2例，III型31例，IV型35例）。通过临床检查和曲面断层片来获取DI、龋齿状况、错牙合、反牙合、开牙合、萌出、阻生和牙齿缺失与OI的患病率及相关性。OI患者中DI的患病率为47.1%，在III型OI中比IV型更常见。在乳牙列中，黄棕色变色型比乳光灰色型更容易磨损。OI似乎没有高龋齿风险；龋齿患病率为69.1%。观察到错牙合、反牙合和开牙合的高发病率。深入的口腔信息将为更好地管理OI患者的牙齿提供有价值的数据。家长和全科医生应更加重视口腔护理，以预防龋齿和过早牙齿脱落。
