Facoltà di Scienze Biomediche, Università della Svizzera Italiana, 6900 Lugano, Switzerland.
Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland.
Nutrients. 2021 Apr 26;13(5):1467. doi: 10.3390/nu13051467.
Vitamin D has been claimed to be effective in the response to infections, including the respiratory syndrome coronavirus 2 (SARS-CoV-2). It is supposed that lockdown measures and fear of SARS-CoV-2 infection might reduce vitamin D levels through the modification of lifestyle. However, very few data exist on the association between lockdown measures and vitamin D status in humans. For this cross-sectional comparative study, adolescents ( = 298) aged 18 to 19 years were enrolled during the compulsory military fitness-for-duty evaluation between July and December 2020 in Southern Switzerland. Beyond anthropometric measurements, participants filled in a structured questionnaire about their lifestyle and a blood specimen was sampled for the determination of total 25-hydroxy-vitamin D. The obtained data were compared with those of 437 adolescents enrolled at the military fitness-for-duty evaluation during the same period of the year in the context of the CENERI study (2014-2016). The anthropometric measures were similar between the two study groups. The levels of vitamin D were also comparable (77 (64-91) vs. 74 (60-92) nmol/L, = 0.50; median and interquartile range). A total of 38 (13%) and 43 (9.8%) subjects presented insufficient (<50 nmol/L) levels of vitamin D ( = 0.42) during the current pandemic and in the CENERI study, respectively. These data do not support the hypothesis that during the SARS-CoV-2 pandemic, late adolescents are at higher risk of vitamin insufficiency.
维生素 D 据称可有效应对感染，包括呼吸道综合征冠状病毒 2（SARS-CoV-2）。据推测，封锁措施和对 SARS-CoV-2 感染的恐惧可能会通过改变生活方式来降低维生素 D 水平。然而，关于封锁措施与人类维生素 D 状况之间的关联，几乎没有数据。在这项横断面比较研究中，2020 年 7 月至 12 月期间，在瑞士南部，对 18 至 19 岁的青少年（n = 298）进行了强制性兵役体检。除了人体测量外，参与者还填写了一份关于其生活方式的结构化问卷，并采集了血液样本以测定总 25-羟维生素 D。将获得的数据与 CENERI 研究（2014-2016 年）同期在兵役体检中招募的 437 名青少年的数据进行了比较。两组研究对象的人体测量指标相似。维生素 D 水平也相似（77（64-91）与 74（60-92）nmol/L， = 0.50；中位数和四分位间距）。在当前大流行期间和 CENERI 研究中，分别有 38（13%）和 43（9.8%）的受试者存在维生素 D 不足（<50 nmol/L）（ = 0.42）。这些数据不支持这样的假设，即在 SARS-CoV-2 大流行期间，青少年后期维生素不足的风险更高。
