活性氧清除剂对脱氢-L-抗坏血酸或其降解产物催化的亚油酸过氧化反应的影响。
Effects of active oxygen scavengers on the peroxidation of linoleic acid catalyzed by dehydro-L-ascorbic acid or its degradation products.
作者信息
Takagi M, Onodera H, Miyamoto I, Morita N
机构信息
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.
出版信息
J Nutr Sci Vitaminol (Tokyo). 1988 Feb;34(1):141-9. doi: 10.3177/jnsv.34.141.
The addition of 1,4-diazabicyclo-[2,2,2]octane (DABCO) (100 mM) or 1,2-dihydroxybenzene-3,5-disulfonic acid (Tiron) (1 mM) to a reaction mixture containing 10 mM linoleic acid (LA), 20% EtOH, and 135 microM dehydroascorbic acid (DHA) as a catalyst suppressed LA peroxidation, but the addition of mannitol (approximately 100 mM), uric acid (100 microM), and catalase (6.5 units) did not. DHA or 2,3-diketo-L-gulonic acid (DKG) accelerated LA peroxidation, but the splitting products of DHA did not affect LA peroxidation. These results suggest that some specific radicals are liberated in the degradation of DHA or DKG.
向含有10 mM亚油酸（LA）、20%乙醇和135 μM脱氢抗坏血酸（DHA）作为催化剂的反应混合物中添加1,4-二氮杂双环-[2,2,2]辛烷（DABCO）（100 mM）或1,2-二羟基苯-3,5-二磺酸（钛铁试剂）（1 mM）可抑制LA过氧化，但添加甘露醇（约100 mM）、尿酸（100 μM）和过氧化氢酶（6.5单位）则不能。DHA或2,3-二酮-L-古洛糖酸（DKG）加速了LA过氧化，但DHA的分解产物不影响LA过氧化。这些结果表明，在DHA或DKG降解过程中会释放出一些特定的自由基。
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