快速连续光流合成天然芳基萘木脂素及其类似物。
Rapid continuous photoflow synthesis of naturally occurring arylnaphthalene lignans and their analogs.
机构信息
School of Pharmacy, Nantong University, Nantong, People's Republic of China.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, People's Republic of China.
出版信息
Nat Prod Res. 2022 Oct;36(19):5086-5090. doi: 10.1080/14786419.2021.1920019. Epub 2021 Apr 30.
Naturally occurring arylnaphthalene lignans (ANLs) are subclass of lignans in many dietary or medicinal plants. The progressing interest of ANLs is due to their diversified biological activities. Herein, we developed a convenient method for the preparation of naturally occurring ANLs and their analogs through the continuous photoflow intramolecular Diels-Alder reaction in several minutes under mild conditions with good yields and regioselectivities.[Formula: see text].
天然芳基萘木脂素（ANLs）是许多食用或药用植物中木脂素的一个子类。ANLs 的研究兴趣不断增加，是因为它们具有多样化的生物活性。在此，我们开发了一种在温和条件下通过连续光流分子内 Diels-Alder 反应在几分钟内制备天然芳基萘木脂素及其类似物的简便方法，产率和区域选择性良好。[公式：见正文]。
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