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光化学在有机合成中的技术创新:流动化学、高通量实验、放大和光电化学。

Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry.

机构信息

Micro Flow Chemistry and Synthetic Methodology, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Bldg 14─Helix, 5600 MB, Eindhoven, The Netherlands.

Flow Chemistry Group, van 't Hoff Institute for Molecular Sciences (HIMS), Universiteit van Amsterdam (UvA), Science Park 904, 1098 XH, Amsterdam, The Netherlands.

出版信息

Chem Rev. 2022 Jan 26;122(2):2752-2906. doi: 10.1021/acs.chemrev.1c00332. Epub 2021 Aug 10.

Abstract

Photoinduced chemical transformations have received in recent years a tremendous amount of attention, providing a plethora of opportunities to synthetic organic chemists. However, performing a photochemical transformation can be quite a challenge because of various issues related to the delivery of photons. These challenges have barred the widespread adoption of photochemical steps in the chemical industry. However, in the past decade, several technological innovations have led to more reproducible, selective, and scalable photoinduced reactions. Herein, we provide a comprehensive overview of these exciting technological advances, including flow chemistry, high-throughput experimentation, reactor design and scale-up, and the combination of photo- and electro-chemistry.

摘要

近年来,光致化学转化受到了极大的关注,为合成有机化学家提供了丰富的机会。然而,由于与光子传递相关的各种问题,进行光化学反应可能是一个相当大的挑战。这些挑战阻碍了光化学步骤在化学工业中的广泛应用。然而,在过去的十年中,一些技术创新带来了更具重现性、选择性和可扩展性的光诱导反应。在此,我们全面概述了这些令人兴奋的技术进步,包括流动化学、高通量实验、反应器设计和放大,以及光电化学的结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eec/8796205/302333e4766c/cr1c00332_0001.jpg

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