Division of Cardiothoracic Surgery, Department of Surgery, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792, USA.
Division of Cardiothoracic Surgery, University of Colorado, Anschutz Medical Campus, 12631 East 17th Avenue, Room 5401, Mail Stop C-291, Aurora, CO 80045, USA.
Thorac Surg Clin. 2021 May;31(2):119-128. doi: 10.1016/j.thorsurg.2021.01.003.
Publication of the National Emphysema Treatment Trial (NETT) in 2003 established lung volume reduction surgery (LVRS) as a viable treatment of select patients with moderate to severe emphysema, and the only intervention since the availability of ambulatory supplemental oxygen to improve survival. Despite these findings, surgical treatment has been underused in part because of concern for high morbidity and mortality. This article reviews recent literature generated since the original NETT publication, focusing on physiologic implications of LVRS, recent data regarding the safety and durability of LVRS, and patient selection and extension of NETT criteria to other patient populations.
2003 年，国家肺气肿治疗试验（NETT）的发表确立了肺减容手术（LVRS）作为治疗中重度肺气肿的一种可行方法，这也是自可移动补充氧气以来唯一能改善生存率的干预措施。尽管有这些发现，但手术治疗的应用仍然不足，部分原因是担心高发病率和死亡率。本文回顾了自原始 NETT 出版物发表以来产生的最新文献，重点介绍了 LVRS 的生理学意义、LVRS 安全性和耐久性的最新数据，以及 NETT 标准在其他患者群体中的选择和扩展。
