Department of Radiology and Neurology, Penn State Health, Hershey Medical Center, Mail Code H066, 500 University Drive, Hershey, PA 17033, USA.
Department of Neurosurgery and Otolaryngology, Penn State Health, 30 Hope Drive, Hershey, PA 17033, USA.
Radiol Clin North Am. 2021 May;59(3):305-322. doi: 10.1016/j.rcl.2021.01.001. Epub 2021 Mar 24.
Molecular features are now essential in distinguishing between glioma histologic subtypes. Currently, isocitrate dehydrogenase mutation, 1p19q codeletion, and MGMT methylation status play significant roles in optimizing medical and surgical treatment. Noninvasive pretreatment and post-treatment determination of glioma subtype is of great interest. Although imaging cannot replace the genetic panel at present, image findings have shown promising signs to identify and diagnose the types and subtypes of gliomas. This article details key imaging findings in the most common molecular glioma subtypes and highlights recent advances in imaging technologies to differentiate these lesions noninvasively.
分子特征现在对于区分胶质瘤的组织学亚型至关重要。目前，异柠檬酸脱氢酶突变、1p19q 缺失和 MGMT 甲基化状态在优化医学和手术治疗方面发挥着重要作用。对胶质瘤亚型进行无创的治疗前和治疗后测定非常重要。尽管目前影像学还不能替代基因检测，但影像学表现已经显示出有希望的迹象来识别和诊断胶质瘤的类型和亚型。本文详细介绍了最常见的分子胶质瘤亚型的关键影像学表现，并强调了影像学技术在这些病变的无创鉴别方面的最新进展。
