Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza L. Miraglia 2, 80138, Naples, Italy.
Division of Endocrinology and Metabolic Diseases, University of Campania "Luigi Vanvitelli", Naples, Italy.
Hormones (Athens). 2021 Sep;20(3):475-482. doi: 10.1007/s42000-021-00295-1. Epub 2021 Apr 30.
Erectile dysfunction (ED) and premature ejaculation (PE) are common sexual disorders in people with diabetes. Glucose variability (GV) has been recognized as a predictor of microvascular complications. The aim of this study was to investigate the relationship between glucose variability and sexual dysfunctions in young men with type 1 diabetes.
One hundred and twelve patients with type 1 diabetes, aged 18-30 years, were enrolled. Patients were divided into two groups according to glucose variability [group 1 (high GV with coefficient of variation ≥ 36%)] and group 2 (low GV with coefficient of variation < 36%)). The presence of sexual dysfunctions was investigated with validated questionnaires.
ED and PE prevalence rates in group 1 were 26% and 13%, respectively. Similarly, in group 2, the prevalence of ED was 24%, and the prevalence of PE was 13%. In both groups, no significant associations between sexual dysfunctions and parameters of glucose variability were found. Multiple regression analysis identified age and depression as independent predictors of ED and PE.
Young male patients affected by type 1 diabetes with high or low glucose variability show a similar prevalence of sexual dysfunctions. ED is the most common sexual dysfunction in diabetic men. Age and depression were the only independent predictive factors for sexual dysfunctions in this population.
勃起功能障碍（ED）和早泄（PE）是糖尿病患者常见的性功能障碍。血糖变异性（GV）已被认为是微血管并发症的预测指标。本研究旨在探讨 1 型糖尿病年轻男性血糖变异性与性功能障碍之间的关系。
共纳入 112 例年龄在 18-30 岁的 1 型糖尿病患者。根据血糖变异性将患者分为两组[组 1（变异系数≥36%）和组 2（变异系数<36%）]。采用经过验证的问卷评估性功能障碍的存在。
组 1 的 ED 和 PE 患病率分别为 26%和 13%。同样，在组 2 中，ED 的患病率为 24%，PE 的患病率为 13%。两组之间，性功能障碍与血糖变异性参数之间均无显著关联。多因素回归分析发现年龄和抑郁是 ED 和 PE 的独立预测因素。
患有高或低血糖变异性的 1 型糖尿病年轻男性患者性功能障碍的患病率相似。ED 是糖尿病男性最常见的性功能障碍。年龄和抑郁是该人群性功能障碍的唯一独立预测因素。
