Department of Surgical, Medical and Experimental Sciences, University of Sassari, Sassari, Italy.
Eur Rev Med Pharmacol Sci. 2021 Apr;25(8):3264-3271. doi: 10.26355/eurrev_202104_25735.
Subclinical hyperthyroidism (SHyper), defined as reduced thyrotropin with free hormones within the reference range, is a common medical finding, in particular in elderly people. In the last years has gained attention due to its health-related conditions, in particular at the cardiovascular level.
We searched electronic database (PubMed) and search engines (Google Scholar) of articles and reviews using the terms "subclinical hyperthyroidism", "Atrial fibrillation", Ischemic stroke", "Hypertension", Heart failure", and "Mortality".
Subclinical hyperthyroidism was clearly associated with the onset of atrial fibrillation and, consequently, with ischemic stroke. However, the latter association is less clear. The effect on hypertension is doubtful and fair. Subclinical hyperthyroidism could increase the risk of acute heart failure, possibly by increasing heart rhythm. Data on mortality are scanty but seem to suggest a possible association, probably linked to the detrimental effect on the cardiovascular system.
Current findings mainly described possible associations with rhythm alterations, heart failure, and stroke but the effective beneficial effects of the treatment of subclinical hyperthyroidism are still lacking.
亚临床甲状腺功能亢进症（SHyper）定义为促甲状腺激素降低而游离激素在参考范围内，是一种常见的医学发现，特别是在老年人中。近年来，由于其与健康相关的状况，特别是在心血管水平上，引起了人们的关注。
我们使用“亚临床甲状腺功能亢进症”、“心房颤动”、“缺血性中风”、“高血压”、“心力衰竭”和“死亡率”等术语，在电子数据库（PubMed）和文章搜索引擎（Google Scholar）中搜索文章和综述。
亚临床甲状腺功能亢进症与心房颤动的发生明显相关，进而与缺血性中风相关。然而，后者的关联不太明确。对高血压的影响存在争议，效果尚可。亚临床甲状腺功能亢进症可能会增加急性心力衰竭的风险，可能是通过增加心律失常。关于死亡率的数据很少，但似乎表明存在可能的关联，可能与对心血管系统的有害影响有关。
目前的研究结果主要描述了与节律改变、心力衰竭和中风的可能关联，但亚临床甲状腺功能亢进症的治疗的有效益处仍缺乏证据。
