Institut Mutualiste Monsouris, Paris, France.
Department of Colorectal Surgery, Saifee Hospital, Mumbai, India.
J Comp Eff Res. 2021 Jul;10(10):801-813. doi: 10.2217/cer-2021-0038. Epub 2021 Apr 30.
Hemorrhoidal disease (HD) is common in adults. Treatment is largely conservative, although more invasive procedures may be required. Venoactive drugs such as micronized purified flavonoid fraction (MPFF) are widely used, but a recent and comprehensive review of supporting evidence is lacking. In acute HD, MPFF can reduce HD symptoms such as bleeding, pain, anal discomfort, anal discharge and pruritus. In patients undergoing surgery, postoperative adjunct MPFF consistently reduces pain, bleeding duration and use of analgesia. MPFF treatment is appropriate and effective both as a first-line conservative treatment and as a postoperative adjunct treatment. MPFF reduces the duration of hospital stay following surgery, facilitating a return to normal activity and improving quality of life. MPFF may also prevent HD recurrence.
痔病（HD）在成年人中很常见。治疗主要采用保守方法，但也可能需要更具侵袭性的方法。静脉活性药物如微粒化纯化黄酮类混合物（MPFF）被广泛应用，但缺乏对其支持证据的近期全面审查。在急性 HD 中，MPFF 可减轻出血、疼痛、肛门不适、肛门分泌物和瘙痒等症状。对于接受手术的患者，术后辅助应用 MPFF 可持续减轻疼痛、出血持续时间和镇痛药物的使用。MPFF 作为一线保守治疗和术后辅助治疗均合理有效。MPFF 可缩短手术后的住院时间，促进恢复正常活动并提高生活质量。MPFF 还可能预防 HD 复发。
