Life and Health College, Anhui Science and Technology University, Fengyang, 233100, China and School of Chemical Engineering, Anhui University of Science and Technology, Huainan, 232001, China.
School of Chemical Engineering, Anhui University of Science and Technology, Huainan, 232001, China.
Chem Commun (Camb). 2021 May 27;57(43):5338-5341. doi: 10.1039/d1cc01044a.
A NaI-promoted sequential double carbon-sulfur bond formation was developed to afford sulfur-bridged imidazopyridines, using Deoxofluor as the sulfur source and requiring only 15 min at room temperature. Using this process, imidazo[1,5-a]pyridines could also be transformed to 1,2,4-thiadiazoles in the presence of ammonium salt with the formation of both carbon-sulfur and nitrogen-sulfur bonds. This mechanistically unique method is distinguished by its wide substrate scope, lack of requirement for transition metals and mild conditions.
一种 NaI 促进的串联双碳-硫键形成反应被开发出来，用于合成含硫桥的咪唑并吡啶，其中 Deoxofluor 作为硫源，在室温下仅需 15 分钟。使用该方法，在铵盐存在下，咪唑并[1,5-a]吡啶也可以转化为 1,2,4-噻二唑，同时形成碳-硫键和氮-硫键。这种具有独特机制的方法的特点是底物适用范围广，不需要过渡金属，反应条件温和。
